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Oncogene
Katzir, N., Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Arman, E., Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Cohen, D., Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Givol, D., Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Rechavi, G., Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
We determined the sequence of the 1.5-kb insert upstream to c-myc in the transmissible venereal tumor (TVT) of dogs. The sequence is highly homologous to the 3' region of the mammalian repetitive LINE element. The insert is bound by a 10-bp repeat indicating DNA transposition by a mechanism involving reverse transcriptase. We analysed DNA of four TVT tumors from various geographical locations as well as normal canine DNA for the presence of the LINE insert. The results indicate that in all TVT tumurs, but not in normal tissues, the same LINE insert was present upstream to c-myc. This result suggests that TVT tumors in various dogs may have a common cellular origin.
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Common origin of transmissible venereal tumors (TVT) in dogs
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Katzir, N., Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Arman, E., Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Cohen, D., Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Givol, D., Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Rechavi, G., Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Common origin of transmissible venereal tumors (TVT) in dogs
We determined the sequence of the 1.5-kb insert upstream to c-myc in the transmissible venereal tumor (TVT) of dogs. The sequence is highly homologous to the 3' region of the mammalian repetitive LINE element. The insert is bound by a 10-bp repeat indicating DNA transposition by a mechanism involving reverse transcriptase. We analysed DNA of four TVT tumors from various geographical locations as well as normal canine DNA for the presence of the LINE insert. The results indicate that in all TVT tumurs, but not in normal tissues, the same LINE insert was present upstream to c-myc. This result suggests that TVT tumors in various dogs may have a common cellular origin.
Scientific Publication
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