Eitan, A., Department of Biology, Research and Development Authority, Ben-Gurion University of the Neger, Beer-Sheva, Israel
Aloni, B., Department of Biology, Research and Development Authority, Ben-Gurion University of the Neger, Beer-Sheva, Israel
Livne, A., Department of Biology, Research and Development Authority, Ben-Gurion University of the Neger, Beer-Sheva, Israel

Camel erythrocyte membranes are distinguished by some unique properties of stability and composition. Notable is their abundance in proteins (protein: lipid ratio of 3 : 1). Membrane proteins of camel erythrocytes were compared with those of human erythrocytes, which have been intensively investigated. Proteins were extracted with various aqueous media (EDTA, alkaline or high ionic strength) and with ionic and non-ionic detergents and were analyzed by gel electrophoresis. In membranes of camel erythrocytes, the peripheral proteins constitute, proportionally, a much smaller fraction of total proteins than in the human erythrocyte, while their distribution is identical per unit of surface area. The camel erythrocyte membrane is particularly rich in integral proteins and in intramembranous particles. The proteins in this membrane are more closely organized than in the human system, as revealed by crosslinking and freeze-etching studies. It is proposed that protein-protein interaction of integral proteins, presumably constituting an "integral skeleton", is a dominant structural feature stabilizing the camel erythrocyte membrane. © 1976.