Advanced Search
Syntax
Search...
Volcani treasures
About
Terms of use
Manage
Community:
אסיף מאגר המחקר החקלאי
Powered by ClearMash Solutions Ltd -
TranspoGene and microTranspoGene: Transposed elements influence on the transcriptome of seven vertebrates and invertebrates
Year:
2008
Source of publication :
Nucleic Acids Research
Authors :
Sela, Noa
;
.
Volume :
36
Co-Authors:
Levy, A., Department of Molecular Genetics and Biochemistry, Tel-Aviv University Medical School, Tel Aviv 69978, Israel
Sela, N., Department of Molecular Genetics and Biochemistry, Tel-Aviv University Medical School, Tel Aviv 69978, Israel
Ast, G., Department of Molecular Genetics and Biochemistry, Tel-Aviv University Medical School, Tel Aviv 69978, Israel
Facilitators :
From page:
To page:
(
Total pages:
1
)
Abstract:
Transposed elements (TEs) are mobile genetic sequences. During the evolution of eukaryotes TEs were inserted into active protein-coding genes, affecting gene structure, expression and splicing patterns, and protein sequences. Genomic insertions of TEs also led to creation and expression of new functional non-coding RNAs such as microRNAs. We have constructed the TranspoGene database, which covers TEs located inside protein-coding genes of seven species: human, mouse, chicken, zebrafish, fruit fly, nematode and sea squirt. TEs were classified according to location within the gene: proximal promoter TEs, exonized TEs (insertion within an intron that led to exon creation), exonic TEs (insertion into an existing exon) or intronic TEs. TranspoGene contains information regarding specific type and family of the TEs, genomic and mRNA location, sequence, supporting transcript accession and alignment to the TE consensus sequence. The database also contains host gene specific data: gene name, genomic location, Swiss-Prot and RefSeq accessions, diseases associated with the gene and splicing pattern. In addition, we created microTranspoGene: a database of human, mouse, zebrafish and nematode TE-derived microRNAs. The TranspoGene and microTranspoGene databases can be used by researchers interested in the effect of TE insertion on the eukaryotic transcriptome. Publicly available query interfaces to TranspoGene and microTranspoGene are available at http://transpogene.tau.ac.il/ and http://microtranspogene.tau.ac.il, respectively. The entire database can be downloaded as flat files. © 2007 The Author(s).
Note:
Related Files :
Animals
Danio rerio
Evolution
gene expression
genomics
mice
proteins
untranslated RNA
Show More
Related Content
More details
DOI :
10.1093/nar/gkm949
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
26854
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:25
You may also be interested in
Scientific Publication
TranspoGene and microTranspoGene: Transposed elements influence on the transcriptome of seven vertebrates and invertebrates
36
Levy, A., Department of Molecular Genetics and Biochemistry, Tel-Aviv University Medical School, Tel Aviv 69978, Israel
Sela, N., Department of Molecular Genetics and Biochemistry, Tel-Aviv University Medical School, Tel Aviv 69978, Israel
Ast, G., Department of Molecular Genetics and Biochemistry, Tel-Aviv University Medical School, Tel Aviv 69978, Israel
TranspoGene and microTranspoGene: Transposed elements influence on the transcriptome of seven vertebrates and invertebrates
Transposed elements (TEs) are mobile genetic sequences. During the evolution of eukaryotes TEs were inserted into active protein-coding genes, affecting gene structure, expression and splicing patterns, and protein sequences. Genomic insertions of TEs also led to creation and expression of new functional non-coding RNAs such as microRNAs. We have constructed the TranspoGene database, which covers TEs located inside protein-coding genes of seven species: human, mouse, chicken, zebrafish, fruit fly, nematode and sea squirt. TEs were classified according to location within the gene: proximal promoter TEs, exonized TEs (insertion within an intron that led to exon creation), exonic TEs (insertion into an existing exon) or intronic TEs. TranspoGene contains information regarding specific type and family of the TEs, genomic and mRNA location, sequence, supporting transcript accession and alignment to the TE consensus sequence. The database also contains host gene specific data: gene name, genomic location, Swiss-Prot and RefSeq accessions, diseases associated with the gene and splicing pattern. In addition, we created microTranspoGene: a database of human, mouse, zebrafish and nematode TE-derived microRNAs. The TranspoGene and microTranspoGene databases can be used by researchers interested in the effect of TE insertion on the eukaryotic transcriptome. Publicly available query interfaces to TranspoGene and microTranspoGene are available at http://transpogene.tau.ac.il/ and http://microtranspogene.tau.ac.il, respectively. The entire database can be downloaded as flat files. © 2007 The Author(s).
Scientific Publication
נגישות
menu      
You may also be interested in