אסיף מאגר המחקר החקלאי

Outward transcutaneous chemical migration: Implications for diagnostics and dosimetry

Year:

1988

Source of publication :

Authors :

Volume :

1

Co-Authors:

Peck, C.C., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Conner, D.P., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Bolden, B.J., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Almirez, R.G., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Kingsley, T.E., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Mell, L.D., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Murphy, M.G., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Hill, V.E., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Rowland, L.M., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Ezra, D., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Kwiatkowski, T.E., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Bradley, C.R., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Abdel-Rahim, M., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States

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Abstract:

Chemical substances migrate outwards from within the body to the skin surface by diffusion from cutaneous capillaries across the epidermis. Heretofore, study of transepidermal chemical emissions have been restricted to substances which are in the vapor phase at skin surface temperature. We have investigated outward transcutaneous chemical migration of nongaseous chemicals by devising an occlusive transcutaneous chemical collection system, consisting of a tape-encased plug of gelled saline in which activated carbon is dispersed. Investigations of nine chemicals in ‘fuzzy’ rats, rhesus monkeys, and man provide data which are consistent with a general theory of outward transcutaneous chemical migration. This noninvasive continuous transcutaneous sampling technique provides a new method for investigating skin permeability in vivo and may provide a basis for convenient diagnosis and monitoring of chemical exposure. © 1988 S. Karger AG, Basel.

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