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Nachtomi, E., Division of Animal Nutrition, Volcani Institute of Agricultural Research, Rehovot, Israel
Alumot, E., Division of Animal Nutrition, Volcani Institute of Agricultural Research, Rehovot, Israel
Pool size and rate of elimination of ethylene dibromide (EDB) and carbon tetrachloride (CTC) were evaluated in the blood and liver of rats and chicks. In rat liver the pool size was the same for CTC and EDB, but the elimination rate of the latter was about four times greater than that of the former, indicating an efficient detoxification mechanism of EDB. The rate of elimination of the two poisons from the blood of this species was similar. In chicks the pool size of EDB was about seven times that of CTC, while the elimination rate was similar. A pronounced species difference in liver pool size resulting from CTC and EDB treatment was observed. In rats CTC was 17 times that in chicks, while EDB was only twice that observed in chicks. The EDB and CTC levels and the elimination rates from the liver may explain their different hepatotoxic effects on the two species, in particular the resistance of chicks to CTC. EDB treatment of rats resulted in a significant rise of triglycerides level in the liver, 12 hours after treatment. Conjugated double bond (diene) formation in microsomal liver lipid of rats treated with EDB was only half of that in CTC-treated rats. None of the poisons caused diene formation in chick liver lipids. There is no apparent relationship between the degree of haloalkanes toxicity and the formation of conjugated double bonds in liver microsomal lipids. © 1972.
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Comparison of ethylene dibromide and carbon tetrachloride toxicity in rats and chicks: Blood and liver levels; lipid peroxidation
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Nachtomi, E., Division of Animal Nutrition, Volcani Institute of Agricultural Research, Rehovot, Israel
Alumot, E., Division of Animal Nutrition, Volcani Institute of Agricultural Research, Rehovot, Israel
Comparison of ethylene dibromide and carbon tetrachloride toxicity in rats and chicks: Blood and liver levels; lipid peroxidation
Pool size and rate of elimination of ethylene dibromide (EDB) and carbon tetrachloride (CTC) were evaluated in the blood and liver of rats and chicks. In rat liver the pool size was the same for CTC and EDB, but the elimination rate of the latter was about four times greater than that of the former, indicating an efficient detoxification mechanism of EDB. The rate of elimination of the two poisons from the blood of this species was similar. In chicks the pool size of EDB was about seven times that of CTC, while the elimination rate was similar. A pronounced species difference in liver pool size resulting from CTC and EDB treatment was observed. In rats CTC was 17 times that in chicks, while EDB was only twice that observed in chicks. The EDB and CTC levels and the elimination rates from the liver may explain their different hepatotoxic effects on the two species, in particular the resistance of chicks to CTC. EDB treatment of rats resulted in a significant rise of triglycerides level in the liver, 12 hours after treatment. Conjugated double bond (diene) formation in microsomal liver lipid of rats treated with EDB was only half of that in CTC-treated rats. None of the poisons caused diene formation in chick liver lipids. There is no apparent relationship between the degree of haloalkanes toxicity and the formation of conjugated double bonds in liver microsomal lipids. © 1972.
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