Manage
Community:
אסיף מאגר המחקר החקלאי
γδ T-lymphocytes and anti-heat shock protein reactivity in bovine leukemia virus infected cattle
Year:
1996
Source of publication :
Veterinary Immunology and ImmunopathologyAuthors :
Moallem, Uzi
;
.
Volume :
51
Co-Authors:
Ungar-Waron, H., Department of Immunology, Kimron Veterinary Institute, 50250 Beit Dagan, Israel
Brenner, J., Department of Immunology, Kimron Veterinary Institute, 50250 Beit Dagan, Israel
Paz, R., Department of Immunology, Kimron Veterinary Institute, 50250 Beit Dagan, Israel
Moalem, U., Volcani Experimental Farm Center, 50250 Beit Dagan, Israel
Trainin, Z., Department of Immunology, Kimron Veterinary Institute, 50250 Beit Dagan, Israel
Brenner, J., Department of Immunology, Kimron Veterinary Institute, 50250 Beit Dagan, Israel
Paz, R., Department of Immunology, Kimron Veterinary Institute, 50250 Beit Dagan, Israel
Moalem, U., Volcani Experimental Farm Center, 50250 Beit Dagan, Israel
Trainin, Z., Department of Immunology, Kimron Veterinary Institute, 50250 Beit Dagan, Israel
Facilitators :
From page:
79
To page:
87
(
Total pages:
9
)
Link :
γδ T-lymphocytes and anti-heat shock protein reactivity in bovine leukemia virus infected cattleAbstract:
Bovine leukemia virus (BLV) induces a chronic infection in cattle that may result in persistent lymphocytosis (PL) and, sometimes, enzootic bovine leukosis. The cellular and humoral immune responses of the host following infection have been extensively investigated but little is known about the involvement of γδ T-cells in BLV pathogenesis. The affluence of these cells in cattle, and particularly in the peripheral blood of young ruminants, may suggest a particular role for them in defense mechanisms. In this study we have examined circulating γδ lymphocytes that express workshop clusters 1 (WC1) and 2 (WC2). In healthy cattle the WC1 cell count tends to decrease with age and adult cattle blood has statistically lower numbers (19.0 ± 6.6%) than that of young animals (40.1 ± 7.2%). However, in the blood of BLV-seropositive adult cattle and mainly in BLV + PL + animals the population of WC1 cells is elevated compared with uninfected animals (P < 0.007). Likewise, the WC2 cell count is increased (P < 0.01) in BLV + PL +. Furthermore, we have investigated whether BLV infection up-regulates the expression of heat shock proteins (HSP) which in turn could augment the humoral response. Anti-HSP70 activity was examined in the sera of 34 BLV-infected cattle and 40 healthy controls by ELISA. Significantly higher activities (P < 0.001) were observed in BLV-infected cattle.
Note:
Related Files :
animal cell
Animals
Antibodies, Monoclonal
cattle
Heat shock proteins
host resistance
virus infection
Show More
Related Content
More details
DOI :
10.1016/0165-2427(95)05495-2
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
27139
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:28
You may also be interested in
Scientific Publication
תפריט נגישות
