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Relationship between endogenous cyclic AMP production and steroid hormone secretion in chick adrenal cells
Year:
1986
Authors :
Hurvitz, Shmuel (Animal science)
;
.
Pines, Mark
;
.
Rosenberg, Jacob
;
.
Volume :
84
Co-Authors:
Rosenberg, J., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, P.O.B. 6, Bet Dagan, 50250, Israel
Pines, M., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, P.O.B. 6, Bet Dagan, 50250, Israel
Hurwitz, S., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, P.O.B. 6, Bet Dagan, 50250, Israel
Facilitators :
From page:
71
To page:
75
(
Total pages:
5
)
Abstract:
1. 1. Dispersed chick adrenal cells were incubated with either ACTH, cholera toxin or forskolin. 2. 2. All three agents stimulated cyclic AMP accumulation and secretion of corticosterone and aldosterone by the dispersed cells. 3. 3. The dose-response to ACTH was similar for cyclic AMP and corticosterone but aldosterone secretion appeared to be more sensitive to ACTH stimulation. 4. 4. Concentrations higher than 10-8 M of ACTH caused suppression of corticosterone output but not of cyclic AMP accumulation or aldosterone secretion. 5. 5. A significant cyclic AMP accumulation occurred within 30 min of exposure to ACTH whereas significant increases in steroid secretion were observed only after 30 min. 6. 6. An early increase (within 30 min) in cyclic AMP accumulation with both cholera toxin and forskolin was not accompanied by any significant stimulation of steroid secretion, which occurred only after 120 min. 7. 7. The results with the avian adrenal cells are consistent with the thesis that steroid production in the adrenocortical cells is stimulated by cyclic AMP-dependent pathways, whereas steroid release may be modulated by others. © 1986.
Note:
Related Files :
adrenal gland
Adrenal Glands
Animal
Chickens
corticosterone
Cyclic AMP
drug effect
In vitro
Kinetics
metabolism
Show More
Related Content
More details
DOI :
10.1016/0305-0491(86)90273-7
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
27171
Last updated date:
21/08/2022 07:45
Creation date:
17/04/2018 00:28
Scientific Publication
Relationship between endogenous cyclic AMP production and steroid hormone secretion in chick adrenal cells
84
Rosenberg, J., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, P.O.B. 6, Bet Dagan, 50250, Israel
Pines, M., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, P.O.B. 6, Bet Dagan, 50250, Israel
Hurwitz, S., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, P.O.B. 6, Bet Dagan, 50250, Israel
Relationship between endogenous cyclic AMP production and steroid hormone secretion in chick adrenal cells
1. 1. Dispersed chick adrenal cells were incubated with either ACTH, cholera toxin or forskolin. 2. 2. All three agents stimulated cyclic AMP accumulation and secretion of corticosterone and aldosterone by the dispersed cells. 3. 3. The dose-response to ACTH was similar for cyclic AMP and corticosterone but aldosterone secretion appeared to be more sensitive to ACTH stimulation. 4. 4. Concentrations higher than 10-8 M of ACTH caused suppression of corticosterone output but not of cyclic AMP accumulation or aldosterone secretion. 5. 5. A significant cyclic AMP accumulation occurred within 30 min of exposure to ACTH whereas significant increases in steroid secretion were observed only after 30 min. 6. 6. An early increase (within 30 min) in cyclic AMP accumulation with both cholera toxin and forskolin was not accompanied by any significant stimulation of steroid secretion, which occurred only after 120 min. 7. 7. The results with the avian adrenal cells are consistent with the thesis that steroid production in the adrenocortical cells is stimulated by cyclic AMP-dependent pathways, whereas steroid release may be modulated by others. © 1986.
Scientific Publication
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