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Lack of leptin activity in blood samples of Adélie penguin and bar-tailed godwit
Year:
2010
Source of publication :
Journal of Endocrinology
Authors :
Yosefi, Sara
;
.
Volume :
207
Co-Authors:
Yosefi, S., Department of Poultry and Aquaculture Sciences, Institute of Animal Science, Agricultural Research Organization (ARO), PO Box 6, Bet Dagan 50250, Israel
Hen, G., Department of Poultry and Aquaculture Sciences, Institute of Animal Science, Agricultural Research Organization (ARO), PO Box 6, Bet Dagan 50250, Israel
Rosenblum, C.I., Merck Research Laboratories, Department of Metabolic Disorders-Diabetes, Rahway, NJ 07065, United States
Cerasale, D.J., Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, United States
Beaulieu, M., Department of Ecology, Physiology and Ethology, Institut Pluridisciplinaire Hubert Curien, CNRS-UdS, 23 Becquerel, 67087 Strasbourg, France
Criscuoloand, F., Department of Ecology, Physiology and Ethology, Institut Pluridisciplinaire Hubert Curien, CNRS-UdS, 23 Becquerel, 67087 Strasbourg, France
Friedman-Einat, M., Department of Poultry and Aquaculture Sciences, Institute of Animal Science, Agricultural Research Organization (ARO), PO Box 6, Bet Dagan 50250, Israel
Facilitators :
From page:
113
To page:
122
(
Total pages:
10
)
Abstract:
Unsuccessful attempts to identify the leptin gene in birds are well documented, despite the characterization of its receptor (LEPR). Since leptin and LEPR have poor sequence conservation among vertebrates, we speculated that a functional assay should represent the best way to detect leptin in birds. Using a leptin bioassay that is based on activation of the chicken LEPR in cultured cells, blood samples from wild birds with extreme seasonal variation in voluntary food intake and fat deposition (Adélie penguins and bar-tailed godwits) were tested for leptin activity. In these experiments, blood samples collected during the pre-incubation and the chick-rearing periods of Adélie penguins, and during the migratory flight and refueling stages of bar-tailed godwits, were found to contain no detectable leptin activity, while the sensitivity of the assay to activation by human blood samples from donor subjects representing a variety of body mass indices and fat contents was clearly demonstrated. These results suggest that in birds, an alternative control mechanism to that of mammals operates in the communication between the body fat tissues and the central control on energy homeostasis. © 2010 Society for Endocrinology.
Note:
Related Files :
adipose tissue
Animal
Animals
Blood
Female
godwit
hormone action
Male
Reproduction
season
Show More
Related Content
More details
DOI :
18
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
27290
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:29
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Scientific Publication
Lack of leptin activity in blood samples of Adélie penguin and bar-tailed godwit
207
Yosefi, S., Department of Poultry and Aquaculture Sciences, Institute of Animal Science, Agricultural Research Organization (ARO), PO Box 6, Bet Dagan 50250, Israel
Hen, G., Department of Poultry and Aquaculture Sciences, Institute of Animal Science, Agricultural Research Organization (ARO), PO Box 6, Bet Dagan 50250, Israel
Rosenblum, C.I., Merck Research Laboratories, Department of Metabolic Disorders-Diabetes, Rahway, NJ 07065, United States
Cerasale, D.J., Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, United States
Beaulieu, M., Department of Ecology, Physiology and Ethology, Institut Pluridisciplinaire Hubert Curien, CNRS-UdS, 23 Becquerel, 67087 Strasbourg, France
Criscuoloand, F., Department of Ecology, Physiology and Ethology, Institut Pluridisciplinaire Hubert Curien, CNRS-UdS, 23 Becquerel, 67087 Strasbourg, France
Friedman-Einat, M., Department of Poultry and Aquaculture Sciences, Institute of Animal Science, Agricultural Research Organization (ARO), PO Box 6, Bet Dagan 50250, Israel
Lack of leptin activity in blood samples of Adélie penguin and bar-tailed godwit
Unsuccessful attempts to identify the leptin gene in birds are well documented, despite the characterization of its receptor (LEPR). Since leptin and LEPR have poor sequence conservation among vertebrates, we speculated that a functional assay should represent the best way to detect leptin in birds. Using a leptin bioassay that is based on activation of the chicken LEPR in cultured cells, blood samples from wild birds with extreme seasonal variation in voluntary food intake and fat deposition (Adélie penguins and bar-tailed godwits) were tested for leptin activity. In these experiments, blood samples collected during the pre-incubation and the chick-rearing periods of Adélie penguins, and during the migratory flight and refueling stages of bar-tailed godwits, were found to contain no detectable leptin activity, while the sensitivity of the assay to activation by human blood samples from donor subjects representing a variety of body mass indices and fat contents was clearly demonstrated. These results suggest that in birds, an alternative control mechanism to that of mammals operates in the communication between the body fat tissues and the central control on energy homeostasis. © 2010 Society for Endocrinology.
Scientific Publication
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