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Polymorphisms in the TNF-α promoter and variability in the granulomatous response in patients with Crohn's disease
Year:
2006
Source of publication :
Pediatric Research
Authors :
Fridlender, Marcelo
;
.
Volume :
59
Co-Authors:
Dalal, I., Department of Pediatrics, E. Wolfson Medical Center, Holon 58100, Israel, Faculty of Medicine, Tel Aviv University, Sackler School of Medicine, Tel Aviv 69978, Israel
Karban, A., Division of Gastroenterology, Rambam Medical Center, Haifa 31096, Israel
Wine, E., Department of Pediatrics, E. Wolfson Medical Center, Holon 58100, Israel
Eliakim, R., Division of Gastroenterology, Rambam Medical Center, Haifa 31096, Israel
Shirin, H., Department of Gastroenterology, E. Wolfson Medical Center, Holon 58100, Israel, Faculty of Medicine, Tel Aviv University, Sackler School of Medicine, Tel Aviv 69978, Israel
Fridlender, M., Danyel Biotech Ltd., Rehovot 76124, Israel
Shaoul, R., Department of Pediatrics, Bnai Zion Medical Center, Haifa 31048, Israel
Leshinsky-Silver, E., Molecular Genetics Laboratory, E. Wolfson Medical Center, Holon 58100, Israel
Levine, A., Pediatric Gastroenterology Unit, E. Wolfson Medical Center, Holon 58100, Israel, Faculty of Medicine, Tel Aviv University, Sackler School of Medicine, Tel Aviv 69978, Israel, Pediatric Gastroenterology Unit, E. Wolfson Medical Center, POB 5, Holon 58100, Israel
Facilitators :
From page:
825
To page:
828
(
Total pages:
4
)
Abstract:
Granulomas may be found in 30-70% of patients with Crohn's disease (CD). The etiology of granuloma formation in CD is presently unknown. Elevated levels of TNF-α are found within granuloma tissue, and are required to maintain granuloma formation in animal models. TNF-α production has been shown to influenced by TNF-α promoter polymorphisms. We hypothesized that heterogeneity for granulomas in CD might be influenced by the TNF-α promoter genotype. Patients with confirmed CD that had undergone full colonoscopy with multiple biopsies and/or surgical resection, served as the study group. One hundred healthy individuals served as a control population for genotyping. Patients and controls underwent genotyping for four TNF-α polymorphisms: 238G/A, 308 G/A,857 C/T, and 863 C/A. Inclusion and exclusion criteria were met in 155 patients (1-68 y). Polymorphisms in the TNF promoter were found in 16.6% (238G/A), 14.5% (308 G/A), 36.6% (857 C/T) and 30.7% (863G/A). No significant association was found for any of the individual polymorphisms with presence or absence of granulomas. In conclusion, we did not find an association between individual polymorphisms in the TNF-α promoter and presence of granulomas in CD. The reason for heterogeneity in granuloma formation in patients with CD remains elusive. Copyright © 2006 International Pediatric Research Foundation, Inc.
Note:
Related Files :
adult
Case-Control Studies
disease association
Female
Genetics
Male
Pathology
tumor necrosis factor alpha
Show More
Related Content
More details
DOI :
10.1203/01.pdr.0000215028.19269.94
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
27398
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:30
Scientific Publication
Polymorphisms in the TNF-α promoter and variability in the granulomatous response in patients with Crohn's disease
59
Dalal, I., Department of Pediatrics, E. Wolfson Medical Center, Holon 58100, Israel, Faculty of Medicine, Tel Aviv University, Sackler School of Medicine, Tel Aviv 69978, Israel
Karban, A., Division of Gastroenterology, Rambam Medical Center, Haifa 31096, Israel
Wine, E., Department of Pediatrics, E. Wolfson Medical Center, Holon 58100, Israel
Eliakim, R., Division of Gastroenterology, Rambam Medical Center, Haifa 31096, Israel
Shirin, H., Department of Gastroenterology, E. Wolfson Medical Center, Holon 58100, Israel, Faculty of Medicine, Tel Aviv University, Sackler School of Medicine, Tel Aviv 69978, Israel
Fridlender, M., Danyel Biotech Ltd., Rehovot 76124, Israel
Shaoul, R., Department of Pediatrics, Bnai Zion Medical Center, Haifa 31048, Israel
Leshinsky-Silver, E., Molecular Genetics Laboratory, E. Wolfson Medical Center, Holon 58100, Israel
Levine, A., Pediatric Gastroenterology Unit, E. Wolfson Medical Center, Holon 58100, Israel, Faculty of Medicine, Tel Aviv University, Sackler School of Medicine, Tel Aviv 69978, Israel, Pediatric Gastroenterology Unit, E. Wolfson Medical Center, POB 5, Holon 58100, Israel
Polymorphisms in the TNF-α promoter and variability in the granulomatous response in patients with Crohn's disease
Granulomas may be found in 30-70% of patients with Crohn's disease (CD). The etiology of granuloma formation in CD is presently unknown. Elevated levels of TNF-α are found within granuloma tissue, and are required to maintain granuloma formation in animal models. TNF-α production has been shown to influenced by TNF-α promoter polymorphisms. We hypothesized that heterogeneity for granulomas in CD might be influenced by the TNF-α promoter genotype. Patients with confirmed CD that had undergone full colonoscopy with multiple biopsies and/or surgical resection, served as the study group. One hundred healthy individuals served as a control population for genotyping. Patients and controls underwent genotyping for four TNF-α polymorphisms: 238G/A, 308 G/A,857 C/T, and 863 C/A. Inclusion and exclusion criteria were met in 155 patients (1-68 y). Polymorphisms in the TNF promoter were found in 16.6% (238G/A), 14.5% (308 G/A), 36.6% (857 C/T) and 30.7% (863G/A). No significant association was found for any of the individual polymorphisms with presence or absence of granulomas. In conclusion, we did not find an association between individual polymorphisms in the TNF-α promoter and presence of granulomas in CD. The reason for heterogeneity in granuloma formation in patients with CD remains elusive. Copyright © 2006 International Pediatric Research Foundation, Inc.
Scientific Publication
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