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Liquid-chromatographic assay of cimetidine in plasma and gastric fluid
Year:
1985
Source of publication :
Clinical Chemistry
Authors :
Ezra, David
;
.
Volume :
31
Co-Authors:
Abdel-Rahim, M., Division of Clinical Pharmacology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Ezra, D., Division of Clinical Pharmacology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Peck, C., Division of Clinical Pharmacology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Lazar, J., Division of Clinical Pharmacology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Facilitators :
From page:
621
To page:
623
(
Total pages:
3
)
Abstract:
In this micro-scale method for liquid-chromatographic measurement of cimetidine in 250-μL volumes of plasma or gastric fluid, a combination of organic- and aqueous-phase extractions, and protonation of the internal standard and cimetidine, enabled us to detect 2.0 ng of cimetidine on the column. We also used a radial compression module, which reduced the retention times for cimetidine and the internal standard to only 2.78 and 2.00 min. The speed and sensitivity of this method facilitates analysis of large numbers of samples.
Note:
Related Files :
Female
intravenous drug administration
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More details
DOI :
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
27628
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:32
Scientific Publication
Liquid-chromatographic assay of cimetidine in plasma and gastric fluid
31
Abdel-Rahim, M., Division of Clinical Pharmacology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Ezra, D., Division of Clinical Pharmacology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Peck, C., Division of Clinical Pharmacology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Lazar, J., Division of Clinical Pharmacology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States
Liquid-chromatographic assay of cimetidine in plasma and gastric fluid
In this micro-scale method for liquid-chromatographic measurement of cimetidine in 250-μL volumes of plasma or gastric fluid, a combination of organic- and aqueous-phase extractions, and protonation of the internal standard and cimetidine, enabled us to detect 2.0 ng of cimetidine on the column. We also used a radial compression module, which reduced the retention times for cimetidine and the internal standard to only 2.78 and 2.00 min. The speed and sensitivity of this method facilitates analysis of large numbers of samples.
Scientific Publication
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