נגישות
menu      
Advanced Search
Syntax
Search...
Volcani treasures
About
Terms of use
Manage
Community:
אסיף מאגר המחקר החקלאי
Powered by ClearMash Solutions Ltd -
Assessment of cartilage repair after chondrocyte transplantation with a fibrin-hyaluronan matrix - Correlation of morphological MRI, biochemical T2 mapping and clinical outcome
Year:
2012
Source of publication :
European Journal of Radiology
Authors :
Sharon, Michal
;
.
Volume :
81
Co-Authors:
Eshed, I., Department of Diagnostic Imaging, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Trattnig, S., Department of Radiology, University Hospital of Vienna, Medical University of Vienna, Vienna, Austria
Sharon, M., Department of Diagnostic Imaging, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Arbel, R., Center for Sports Medicine, Sourasky Medical Center, Tel Aviv, Israel
Nierenberg, G., Department of Orthopedics, Rambam Health Care Campus, Haifa, Israel
Konen, E., Department of Diagnostic Imaging, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Yayon, A., ProChon Biotech, Ness Ziona, Israel
Facilitators :
From page:
1216
To page:
1223
(
Total pages:
8
)
Abstract:
Objective: To evaluate change over time of clinical scores, morphological MRI of cartilage appearance and quantitative T2 values after implantation with BioCart™II, a second generation matrix-assisted implantation system. Methods: Thirty-one patients were recruited 6-49 months post surgery for cartilage defect in the femoral condyle. Subjects underwent MRI (morphological and T2-mapping sequences) and completed the International Knee Documentation Committee (IKDC) questionnaire. MRI scans were scored using the MR Observation of Cartilage Repair Tissue (MOCART) system and cartilage T2-mapping values were registered. Analysis included correlation of IKDC scores, MOCART and T2 evaluation with each other, with implant age and with previous surgical intervention history. Results: IKDC score significantly correlated with MOCART score (r = -0.39, p = 0.031), inversely correlated with previous interventions (r = -0.39, p = 0.034) and was significantly higher in patients with longer follow-up time (p = 0.0028). MOCART score was slight, but not significantly higher in patients with longer term implants (p = 0.199). T2 values were significantly lower in patients with longer duration implants (p < 0.001). This trend was repeated in patients with previous interventions, although to a lesser extent. Conclusions: Significant improvement with time from BioCart™II implantation can be expected by IKDC scoring and MRI T2-mapping values. Patients with previous knee operations can also benefit from this procedure. © 2011 Elsevier Ireland Ltd. All rights reserved.
Note:
Related Files :
adult
chondrocyte implantation
clinical article
Female
Magnetic Resonance Imaging
Male
questionnaire
Statistics, Nonparametric
Show More
Related Content
More details
DOI :
10.1016/j.ejrad.2011.03.031
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
27677
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:33
Scientific Publication
Assessment of cartilage repair after chondrocyte transplantation with a fibrin-hyaluronan matrix - Correlation of morphological MRI, biochemical T2 mapping and clinical outcome
81
Eshed, I., Department of Diagnostic Imaging, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Trattnig, S., Department of Radiology, University Hospital of Vienna, Medical University of Vienna, Vienna, Austria
Sharon, M., Department of Diagnostic Imaging, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Arbel, R., Center for Sports Medicine, Sourasky Medical Center, Tel Aviv, Israel
Nierenberg, G., Department of Orthopedics, Rambam Health Care Campus, Haifa, Israel
Konen, E., Department of Diagnostic Imaging, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Yayon, A., ProChon Biotech, Ness Ziona, Israel
Assessment of cartilage repair after chondrocyte transplantation with a fibrin-hyaluronan matrix - Correlation of morphological MRI, biochemical T2 mapping and clinical outcome
Objective: To evaluate change over time of clinical scores, morphological MRI of cartilage appearance and quantitative T2 values after implantation with BioCart™II, a second generation matrix-assisted implantation system. Methods: Thirty-one patients were recruited 6-49 months post surgery for cartilage defect in the femoral condyle. Subjects underwent MRI (morphological and T2-mapping sequences) and completed the International Knee Documentation Committee (IKDC) questionnaire. MRI scans were scored using the MR Observation of Cartilage Repair Tissue (MOCART) system and cartilage T2-mapping values were registered. Analysis included correlation of IKDC scores, MOCART and T2 evaluation with each other, with implant age and with previous surgical intervention history. Results: IKDC score significantly correlated with MOCART score (r = -0.39, p = 0.031), inversely correlated with previous interventions (r = -0.39, p = 0.034) and was significantly higher in patients with longer follow-up time (p = 0.0028). MOCART score was slight, but not significantly higher in patients with longer term implants (p = 0.199). T2 values were significantly lower in patients with longer duration implants (p < 0.001). This trend was repeated in patients with previous interventions, although to a lesser extent. Conclusions: Significant improvement with time from BioCart™II implantation can be expected by IKDC scoring and MRI T2-mapping values. Patients with previous knee operations can also benefit from this procedure. © 2011 Elsevier Ireland Ltd. All rights reserved.
Scientific Publication
You may also be interested in