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Intermediates of stigmasterol metabolism in spodoptera littoralis
Year:
1989
Source of publication :
Steroids
Authors :
Svoboda, James
;
.
Volume :
53
Co-Authors:
Svoboda, J.A., Insect and Nematode Hormone Laboratory, ARS, USDA, Beltsville, MD 20705, United States
Rees, H.H., Department of Biochemistry, University of Liverpool, Liverpool, United Kingdom
Thompson, M.J., Insect and Nematode Hormone Laboratory, ARS, USDA, Beltsville, MD 20705, United States
Hoggard, N., Department of Biochemistry, University of Liverpool, Liverpool, United Kingdom
Facilitators :
From page:
329
To page:
343
(
Total pages:
15
)
Abstract:
Stigmasterol-24,28-epoxide, 22E-stigmasta-5,22,24(28E)-trien-3β-ol, and 22E-cholesta-5,22,24-trien-3β-ol were identified as normal metabolites of [3H]stigmasterol in Spodoptera littoralis larvae. Relative concentrations of all three of these metabolites increased when a diazasterol inhibitor was fed in combination with stigmasterol in the artificial diet. Identification of these sterols as intermediates in the conversion of stigmasterol to cholesterol in this insect indicates that intermediates analogous to fucosterol and fucosterol-24,28-epoxide in the conversion of sitosterol to cholesterol are produced in the metabolism of stigmasterol. This is the first published identification of stigmasterol-24,28-epoxide and 22E-stigmasta-5,22,24(28E)-trien-3β-ol as intermediates in this pathway in an insect. © 1989.
Note:
Related Files :
Animal
Azasteroids
Chromatography, High Pressure Liquid
insects
Phytosterols
sitosterol
tritium
Show More
Related Content
More details
DOI :
10.1016/0039-128X(89)90018-4
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
27826
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:34
Scientific Publication
Intermediates of stigmasterol metabolism in spodoptera littoralis
53
Svoboda, J.A., Insect and Nematode Hormone Laboratory, ARS, USDA, Beltsville, MD 20705, United States
Rees, H.H., Department of Biochemistry, University of Liverpool, Liverpool, United Kingdom
Thompson, M.J., Insect and Nematode Hormone Laboratory, ARS, USDA, Beltsville, MD 20705, United States
Hoggard, N., Department of Biochemistry, University of Liverpool, Liverpool, United Kingdom
Intermediates of stigmasterol metabolism in spodoptera littoralis
Stigmasterol-24,28-epoxide, 22E-stigmasta-5,22,24(28E)-trien-3β-ol, and 22E-cholesta-5,22,24-trien-3β-ol were identified as normal metabolites of [3H]stigmasterol in Spodoptera littoralis larvae. Relative concentrations of all three of these metabolites increased when a diazasterol inhibitor was fed in combination with stigmasterol in the artificial diet. Identification of these sterols as intermediates in the conversion of stigmasterol to cholesterol in this insect indicates that intermediates analogous to fucosterol and fucosterol-24,28-epoxide in the conversion of sitosterol to cholesterol are produced in the metabolism of stigmasterol. This is the first published identification of stigmasterol-24,28-epoxide and 22E-stigmasta-5,22,24(28E)-trien-3β-ol as intermediates in this pathway in an insect. © 1989.
Scientific Publication
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