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The stomach as a bioreactor: Dietary lipid peroxidation in the gastric fluid and the effects of plant-derived antioxidants
Year:
2001
Source of publication :
Free Radical Biology and Medicine
Authors :
Kanner, Joseph
;
.
Volume :
31
Co-Authors:
Kanner, J., Department of Food Science, ARO, the Volcani Center, Bet Dagan, Israel, Department of Food Science, ARO the Volcani Center, Bet Dagan 50250, Israel
Lapidot, T., Department of Food Science, ARO, the Volcani Center, Bet Dagan, Israel
Facilitators :
From page:
1388
To page:
1395
(
Total pages:
8
)
Abstract:
Atherosclerosis may result partly from processes that occur following food consumption and that involve oxidized lipids in chylomicrons. We investigated reactions that could occur in the acidic pH of the stomach and accelerate the generation of lipid hydroperoxides and co-oxidation of dietary constituents. The ability of dietary polyphenols to invert catalysis from pro-oxidation to antioxidation was examined. The acidic pH of gastric fluid amplified lipid peroxidation catalyzed by metmyoglobin or iron ions. Metmyoglobin catalyzed peroxidation of eatable oil, resulting in 8-fold increase of hydroperoxide concentration. The incubation of heated muscle tissue in simulated gastric fluid for 2 h enhanced hydroperoxides accumulation by 6-fold to 1200 μM. In the presence of catechin or red wine polyphenols, metmyoglobin catalyzed the breakdown of hydroperoxides to zero, totally preventing lipid peroxidation and β-carotene cooxidation. We suggest that human gastric fluid may be an excellent medium for enhancing the oxidation of lipids and other dietary constituents. The results indicate the potentially harmful effects of oxidized fats intake in the presence of endogenous catalysts found in foods, and the major benefit of including in the meal plant dietary antioxidants. © 2001 Elsevier Science Inc.
Note:
Related Files :
Animals
animal tissue
antioxidants
flavonoids
free radicals
Fruits
iron
oxidation
phenols
Plants
vegetables
Show More
Related Content
More details
DOI :
10.1016/S0891-5849(01)00718-3
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
27896
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:35
Scientific Publication
The stomach as a bioreactor: Dietary lipid peroxidation in the gastric fluid and the effects of plant-derived antioxidants
31
Kanner, J., Department of Food Science, ARO, the Volcani Center, Bet Dagan, Israel, Department of Food Science, ARO the Volcani Center, Bet Dagan 50250, Israel
Lapidot, T., Department of Food Science, ARO, the Volcani Center, Bet Dagan, Israel
The stomach as a bioreactor: Dietary lipid peroxidation in the gastric fluid and the effects of plant-derived antioxidants
Atherosclerosis may result partly from processes that occur following food consumption and that involve oxidized lipids in chylomicrons. We investigated reactions that could occur in the acidic pH of the stomach and accelerate the generation of lipid hydroperoxides and co-oxidation of dietary constituents. The ability of dietary polyphenols to invert catalysis from pro-oxidation to antioxidation was examined. The acidic pH of gastric fluid amplified lipid peroxidation catalyzed by metmyoglobin or iron ions. Metmyoglobin catalyzed peroxidation of eatable oil, resulting in 8-fold increase of hydroperoxide concentration. The incubation of heated muscle tissue in simulated gastric fluid for 2 h enhanced hydroperoxides accumulation by 6-fold to 1200 μM. In the presence of catechin or red wine polyphenols, metmyoglobin catalyzed the breakdown of hydroperoxides to zero, totally preventing lipid peroxidation and β-carotene cooxidation. We suggest that human gastric fluid may be an excellent medium for enhancing the oxidation of lipids and other dietary constituents. The results indicate the potentially harmful effects of oxidized fats intake in the presence of endogenous catalysts found in foods, and the major benefit of including in the meal plant dietary antioxidants. © 2001 Elsevier Science Inc.
Scientific Publication
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