אסיף מאגר המחקר החקלאי

Tachykinin modulation of coronary blood flow

Year:

1986

Source of publication :

Authors :

Volume :

122

Co-Authors:

Ezra, D., Division of Clinical Pharmacology Uniformed Services University, the Health Services, 4301 Jones Bridge Rd, Bethesda, MD 20814-4799, United States
Laurindo, F.R.M., Division of Cardiology Departments of Pharmacology and Medicine and The Neurobiology Research Division, Department of Neurology, Uniformed Services University of the Health Services, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, U.S.A.
Eimerl, J., Division of Clinical Pharmacology Uniformed Services University, the Health Services, 4301 Jones Bridge Rd, Bethesda, MD 20814-4799, United States, Division of Cardiology Departments of Pharmacology and Medicine and The Neurobiology Research Division, Department of Neurology, Uniformed Services University of the Health Services, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, U.S.A.
Goldstein, R.E., Division of Cardiology Departments of Pharmacology and Medicine and The Neurobiology Research Division, Department of Neurology, Uniformed Services University of the Health Services, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, U.S.A.
Peck, C.C., Division of Clinical Pharmacology Uniformed Services University, the Health Services, 4301 Jones Bridge Rd, Bethesda, MD 20814-4799, United States
Feuerstein, G., Division of Clinical Pharmacology Uniformed Services University, the Health Services, 4301 Jones Bridge Rd, Bethesda, MD 20814-4799, United States, Division of Cardiology Departments of Pharmacology and Medicine and The Neurobiology Research Division, Department of Neurology, Uniformed Services University of the Health Services, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, U.S.A.

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Abstract:

In pentobarbital anesthetized, open chest pigs, coronary blood flow (CBF), myocardial contractility and systemic hemodynamic variables were monitored during intracoronary injections of substance P (SP), neurokinin A (NA) or neurokinin B (NB). SP was most potent in increasing CBF although NA was also active in high doses while NB had absolutely no effect. SP was also more potent than NA in producing systemic hypotension. The data suggests that SP and its receptors might be potentially important modulators of CBF. © 1986.

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