אסיף מאגר המחקר החקלאי

Inhibition of protein secretion and protein kinase activity in the locust fat body by diamide (Azodicarboxylic acid-bis-dimethylamide)

Year:

1978

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Authors :

Volume :

191

Co-Authors:

Harry, P., Department of Entomology, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot, 76 100, Israel
Pines, M., Department of Entomology, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot, 76 100, Israel
Applebaum, S.W., Department of Entomology, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot, 76 100, Israel

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Abstract:

Protein secretion from locust fat body incubated in vitro is instantaneously halted in the presence of diamide (azodicarboxylic acid-bis-dimethylamide). Independent inhibition of amino acid uptake, protein synthesis (verified in cell-free systems), and protein secretion is demonstrated. Diamide inhibits cyclic AMP- and cyclic GMP-dependent protein kinase activity in locust fat body. © 1978.

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