נגישות
menu      
Advanced Search
Syntax
Search...
Volcani treasures
About
Terms of use
Manage
Community:
אסיף מאגר המחקר החקלאי
Powered by ClearMash Solutions Ltd -
BLG-e1 - A novel regulatory element in the distal region of the β-lactoglobulin gene promoter
Year:
2005
Source of publication :
FEBS Letters
Authors :
Barash, Itamar
;
.
German, Tania
;
.
Reichenstein, Moshe
;
.
Volume :
579
Co-Authors:
Reichenstein, M., Institute of Animal Science, ARO, Volcani Center, P.O. Box 6, Bet-Dagan 50250, Israel
German, T., Institute of Animal Science, ARO, Volcani Center, P.O. Box 6, Bet-Dagan 50250, Israel
Barash, I., Institute of Animal Science, ARO, Volcani Center, P.O. Box 6, Bet-Dagan 50250, Israel
Facilitators :
From page:
2097
To page:
2104
(
Total pages:
8
)
Abstract:
β-Lactoglobulin (BLG) is a major ruminant milk protein. A regulatory element, termed BLG-e1, was defined in the distal region of the ovine BLG gene promoter. This 299-bp element lacks the established cis-regulatory sequences that affect milk-protein gene expression. Nevertheless, it alters the binding of downstream BLG sequences to histone H4 and the sensitivity of the histone-DNA complexes to trichostatin A treatment. In mammary cells cultured under favorable lactogenic conditions, BLG-e1 acts as a potent, position-independent silencer of BLG/luciferase expression, and similarly affects the promoter activity of the mouse whey acidic protein gene. Intragenic sequences upstream of BLG exon 2 reverse the silencing effect of BLG-e1 in vitro and in transgenic mice. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Note:
Related Files :
animal cell
Animals
Base Sequence
gene activity
gene silencing
Mammary gland
mice
regulator gene
trichostatin A
Show More
Related Content
More details
DOI :
10.1016/j.febslet.2005.02.061
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
28261
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:37
You may also be interested in
Scientific Publication
BLG-e1 - A novel regulatory element in the distal region of the β-lactoglobulin gene promoter
579
Reichenstein, M., Institute of Animal Science, ARO, Volcani Center, P.O. Box 6, Bet-Dagan 50250, Israel
German, T., Institute of Animal Science, ARO, Volcani Center, P.O. Box 6, Bet-Dagan 50250, Israel
Barash, I., Institute of Animal Science, ARO, Volcani Center, P.O. Box 6, Bet-Dagan 50250, Israel
BLG-e1 - A novel regulatory element in the distal region of the β-lactoglobulin gene promoter
β-Lactoglobulin (BLG) is a major ruminant milk protein. A regulatory element, termed BLG-e1, was defined in the distal region of the ovine BLG gene promoter. This 299-bp element lacks the established cis-regulatory sequences that affect milk-protein gene expression. Nevertheless, it alters the binding of downstream BLG sequences to histone H4 and the sensitivity of the histone-DNA complexes to trichostatin A treatment. In mammary cells cultured under favorable lactogenic conditions, BLG-e1 acts as a potent, position-independent silencer of BLG/luciferase expression, and similarly affects the promoter activity of the mouse whey acidic protein gene. Intragenic sequences upstream of BLG exon 2 reverse the silencing effect of BLG-e1 in vitro and in transgenic mice. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Scientific Publication
You may also be interested in