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Sonodynamic therapya review of the synergistic effects of drugs and ultrasound
Year:
2004
Source of publication :
Ultrasonics Sonochemistry
Authors :
Rosenthal, Ionel
;
.
Volume :
11
Co-Authors:
Rosenthal, I., Radiation Biology Branch, National Cancer Institute, Natl. Institutes Hlth., 20892-1002, Bethesda, MD, United States, Department of Food Science, Volcani Center, Agric. Res. Org., POB 6, 50250, Bet-Dagan, IL, Israel
Sostaric, J.Z., Radiation Biology Branch, National Cancer Institute, Natl. Institutes Hlth., 20892-1002, Bethesda, MD, United States
Riesz, P., Radiation Biology Branch, National Cancer Institute, Natl. Institutes Hlth., 20892-1002, Bethesda, MD, United States, Radiation Biology Branch, National Cancer Institute, Natl. Institutes Hlth., Bldg. 10, R., Bethesda, MD, United States
Facilitators :
From page:
349
To page:
363
(
Total pages:
15
)
Abstract:
Sonodynamic therapy, the ultrasound dependent enhancement of cytotoxic activities of certain compounds (sonosensitizers) in studies with cells in vitro and in tumor bearing animals, is reviewed. The attractive features of this modality for cancer treatment emerges from the ability to focus the ultrasound energy on malignancy sites buried deep in tissues and to locally activate a preloaded sonosensitizer. Possible mechanisms of sonodynamic therapy include generation of sonosensitizer derived radicals which initiate chain peroxidation of membrane lipids via peroxyl and/or alkoxyl radicals, the physical destabilization of the cell membrane by the sonosensitizer thereby rendering the cell more susceptible to shear forces or ultrasound enhanced drug transport across the cell membrane (sonoporation). Evidence against the role of singlet oxygen in sonodynamic therapy is discussed. The mechanism of sonodynamic therapy is probably not governed by a universal mechanism, but may be influenced by multiple factors including the nature of the biological model, the sonosensitizer and the ultrasound parameters. The current review emphasizes the effect of ultrasound induced free radicals in sonodynamic therapy.
Note:
Related Files :
Animal
Animals
Cancer
free radicals
ultrasonics
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Related Content
More details
DOI :
10.1016/j.ultsonch.2004.03.004
Article number:
Affiliations:
Database:
Scopus
Publication Type:
Review
;
.
Language:
English
Editors' remarks:
ID:
28328
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:38
Scientific Publication
Sonodynamic therapya review of the synergistic effects of drugs and ultrasound
11
Rosenthal, I., Radiation Biology Branch, National Cancer Institute, Natl. Institutes Hlth., 20892-1002, Bethesda, MD, United States, Department of Food Science, Volcani Center, Agric. Res. Org., POB 6, 50250, Bet-Dagan, IL, Israel
Sostaric, J.Z., Radiation Biology Branch, National Cancer Institute, Natl. Institutes Hlth., 20892-1002, Bethesda, MD, United States
Riesz, P., Radiation Biology Branch, National Cancer Institute, Natl. Institutes Hlth., 20892-1002, Bethesda, MD, United States, Radiation Biology Branch, National Cancer Institute, Natl. Institutes Hlth., Bldg. 10, R., Bethesda, MD, United States
Sonodynamic therapya review of the synergistic effects of drugs and ultrasound
Sonodynamic therapy, the ultrasound dependent enhancement of cytotoxic activities of certain compounds (sonosensitizers) in studies with cells in vitro and in tumor bearing animals, is reviewed. The attractive features of this modality for cancer treatment emerges from the ability to focus the ultrasound energy on malignancy sites buried deep in tissues and to locally activate a preloaded sonosensitizer. Possible mechanisms of sonodynamic therapy include generation of sonosensitizer derived radicals which initiate chain peroxidation of membrane lipids via peroxyl and/or alkoxyl radicals, the physical destabilization of the cell membrane by the sonosensitizer thereby rendering the cell more susceptible to shear forces or ultrasound enhanced drug transport across the cell membrane (sonoporation). Evidence against the role of singlet oxygen in sonodynamic therapy is discussed. The mechanism of sonodynamic therapy is probably not governed by a universal mechanism, but may be influenced by multiple factors including the nature of the biological model, the sonosensitizer and the ultrasound parameters. The current review emphasizes the effect of ultrasound induced free radicals in sonodynamic therapy.
Scientific Publication
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