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Distribution of fibronectin-binding proteins among group a streptococci of different m types
Year:
1995
Source of publication :
Journal of Infectious Diseases
Authors :
Sela, Shlomo
;
.
Volume :
171
Co-Authors:
Natanson, S., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Sela, S., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Moses, A.E., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Musser, J.M., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Caparon, M.G., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Hanski, E., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Facilitators :
From page:
871
To page:
878
(
Total pages:
8
)
Abstract:
Binding of fibronectin by group A streptococci (GAS) promotes adherence to epithelial cells. The fibronectin-binding activity and the presence of prtF, a gene encoding a fibronectin-binding protein, were studied among 109 strains. Fifty-six strains of 42 different M types possessed prtF-related genes, and 89% of these strains bound fibronectin at high levels. The prtF-related genes varied in the number of repeats that constitute one of its two fibronectin-binding domains. Fifty-three strains of 21 different M types lacked prtF. Thirty-nine of these (74%), representing 13 different M types, bound fibronectin at very low levels. However, 9 (17%), of 5 different M types, bound fibronectin at high levels. The presence of prtF and the capacity to bind fibronectin correlated strongly with the M type of various strains of GAS. This correlation may suggest the existence of a relationship between fibronectin binding and the pathogenic potential of GAS. © 1995, by The University of Chicago.
Note:
Related Files :
Base Sequence
Molecular Sequence Data
protein localization
virulence
Show More
Related Content
More details
DOI :
10.1093/infdis/171.4.871
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
28476
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:39
Scientific Publication
Distribution of fibronectin-binding proteins among group a streptococci of different m types
171
Natanson, S., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Sela, S., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Moses, A.E., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Musser, J.M., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Caparon, M.G., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Hanski, E., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Distribution of fibronectin-binding proteins among group a streptococci of different m types
Binding of fibronectin by group A streptococci (GAS) promotes adherence to epithelial cells. The fibronectin-binding activity and the presence of prtF, a gene encoding a fibronectin-binding protein, were studied among 109 strains. Fifty-six strains of 42 different M types possessed prtF-related genes, and 89% of these strains bound fibronectin at high levels. The prtF-related genes varied in the number of repeats that constitute one of its two fibronectin-binding domains. Fifty-three strains of 21 different M types lacked prtF. Thirty-nine of these (74%), representing 13 different M types, bound fibronectin at very low levels. However, 9 (17%), of 5 different M types, bound fibronectin at high levels. The presence of prtF and the capacity to bind fibronectin correlated strongly with the M type of various strains of GAS. This correlation may suggest the existence of a relationship between fibronectin binding and the pathogenic potential of GAS. © 1995, by The University of Chicago.
Scientific Publication
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