אסיף מאגר המחקר החקלאי

Distribution of fibronectin-binding proteins among group a streptococci of different m types

Year:

1995

Source of publication :

Authors :

Volume :

171

Co-Authors:

Natanson, S., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Sela, S., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Moses, A.E., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Musser, J.M., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Caparon, M.G., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States
Hanski, E., Department of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel, Section of Molecular Pathobiology (Department of Pathology), Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, United States, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MI, United States

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Abstract:

Binding of fibronectin by group A streptococci (GAS) promotes adherence to epithelial cells. The fibronectin-binding activity and the presence of prtF, a gene encoding a fibronectin-binding protein, were studied among 109 strains. Fifty-six strains of 42 different M types possessed prtF-related genes, and 89% of these strains bound fibronectin at high levels. The prtF-related genes varied in the number of repeats that constitute one of its two fibronectin-binding domains. Fifty-three strains of 21 different M types lacked prtF. Thirty-nine of these (74%), representing 13 different M types, bound fibronectin at very low levels. However, 9 (17%), of 5 different M types, bound fibronectin at high levels. The presence of prtF and the capacity to bind fibronectin correlated strongly with the M type of various strains of GAS. This correlation may suggest the existence of a relationship between fibronectin binding and the pathogenic potential of GAS. © 1995, by The University of Chicago.

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