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Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp. (MSU-2110) endophytic on Monstera sp
Year:
2004
Source of publication :
Microbiology
Authors :
Ezra, David
;
.
Volume :
150
Co-Authors:
Ezra, D., Department of Plant Sciences, Montana State University, Bozeman, MT 59717, United States
Castillo, U.F., Department of Plant Sciences, Montana State University, Bozeman, MT 59717, United States
Strobel, G.A., Department of Plant Sciences, Montana State University, Bozeman, MT 59717, United States
Hess, W.M., Department of Integrated Biology, Brigham Young University, Provo, UT 84602, United States
Porter, H., Department of Microbiology, Brigham Young University, Provo, UT 84602, United States
Jensen, J.B., Department of Microbiology, Brigham Young University, Provo, UT 84602, United States
Condron, M.A.M., Department of Neurology, Harvard Medical School, Center for Neurologic Diseases, Boston, MA 02115, United States
Teplow, D.B., Department of Neurology, Harvard Medical School, Center for Neurologic Diseases, Boston, MA 02115, United States
Sears, J., Department of Chemistry, Montana State University, Bozeman, MT 59717, United States
Maranta, M., Novozymes Biotech Inc., 1445 Drew Ave., Davis, CA 95616, United States
Hunter, M., Novozymes Biotech Inc., 1445 Drew Ave., Davis, CA 95616, United States
Weber, B., Novozymes Biotech Inc., 1445 Drew Ave., Davis, CA 95616, United States
Yaver, D., Novozymes Biotech Inc., 1445 Drew Ave., Davis, CA 95616, United States
Facilitators :
From page:
785
To page:
793
(
Total pages:
9
)
Abstract:
Coronamycin is a complex of novel peptide antibiotics with activity against pythiaceous fungi and the human fungal pathogen Cryptococcus neoformans. It is also active against the malarial parasite, Plasmodium falciparum, with an IC50 of 9.0 ng ml-1. Coronamycin is produced by a verticillate Streptomyces sp. isolated as an endophyte from an epiphytic vine, Monstera sp., found in the Manu region of the upper Amazon of Peru. Bioassay-guided fractionation of the fermentation broths of this endophyte on silica gel and HPLC chromatography yielded two principal, inseparable, peptides with masses of 1217.9 and 1203.8 Da. Three other minor, but related components, are also present in the preparation. Amino acid analysis of coronamycin revealed residues of component 1, component 2, methionine, tyrosine and leucine at a ratio of 2: 2: 1: 1: 3. Other compounds with antifungal activities are also produced by this endophytic streptomycete. © 2004 SGM.
Note:
Related Files :
Animals
Araceae
bacteria
Bioassay
endophyte
fungi
peptides
unclassified drug
Show More
Related Content
More details
DOI :
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
28567
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:40
Scientific Publication
Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp. (MSU-2110) endophytic on Monstera sp
150
Ezra, D., Department of Plant Sciences, Montana State University, Bozeman, MT 59717, United States
Castillo, U.F., Department of Plant Sciences, Montana State University, Bozeman, MT 59717, United States
Strobel, G.A., Department of Plant Sciences, Montana State University, Bozeman, MT 59717, United States
Hess, W.M., Department of Integrated Biology, Brigham Young University, Provo, UT 84602, United States
Porter, H., Department of Microbiology, Brigham Young University, Provo, UT 84602, United States
Jensen, J.B., Department of Microbiology, Brigham Young University, Provo, UT 84602, United States
Condron, M.A.M., Department of Neurology, Harvard Medical School, Center for Neurologic Diseases, Boston, MA 02115, United States
Teplow, D.B., Department of Neurology, Harvard Medical School, Center for Neurologic Diseases, Boston, MA 02115, United States
Sears, J., Department of Chemistry, Montana State University, Bozeman, MT 59717, United States
Maranta, M., Novozymes Biotech Inc., 1445 Drew Ave., Davis, CA 95616, United States
Hunter, M., Novozymes Biotech Inc., 1445 Drew Ave., Davis, CA 95616, United States
Weber, B., Novozymes Biotech Inc., 1445 Drew Ave., Davis, CA 95616, United States
Yaver, D., Novozymes Biotech Inc., 1445 Drew Ave., Davis, CA 95616, United States
Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp. (MSU-2110) endophytic on Monstera sp
Coronamycin is a complex of novel peptide antibiotics with activity against pythiaceous fungi and the human fungal pathogen Cryptococcus neoformans. It is also active against the malarial parasite, Plasmodium falciparum, with an IC50 of 9.0 ng ml-1. Coronamycin is produced by a verticillate Streptomyces sp. isolated as an endophyte from an epiphytic vine, Monstera sp., found in the Manu region of the upper Amazon of Peru. Bioassay-guided fractionation of the fermentation broths of this endophyte on silica gel and HPLC chromatography yielded two principal, inseparable, peptides with masses of 1217.9 and 1203.8 Da. Three other minor, but related components, are also present in the preparation. Amino acid analysis of coronamycin revealed residues of component 1, component 2, methionine, tyrosine and leucine at a ratio of 2: 2: 1: 1: 3. Other compounds with antifungal activities are also produced by this endophytic streptomycete. © 2004 SGM.
Scientific Publication
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