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Tolerance and acceptable daily intake of chlorinated fumigants in the rat diet
Year:
1976
Source of publication :
Food and Cosmetics Toxicology
Authors :
Alumot (Olomucki), Eugenia
;
.
Holstein, Pia
;
.
Mandel, E.
;
.
Nachtomi, Edna
;
.
Volume :
14
Co-Authors:


Bondi, A., Faculty of Agriculture, Rehovot, Israel
Herzberg, M., Ichilov Hospital, Tel Aviv, Israel

Facilitators :
From page:
105
To page:
110
(
Total pages:
6
)
Abstract:
Long-term trials were carried out with rats fed mash fumigated with carbon tetrachloride or ethylene dichloride (1,2-dichloroethane). The difficulty of maintaining a constant residual level of fumigant in the feed was overcome by adopting suitable storage and feeding procedures. The amounts of fumigant actually consumed accounted for 60-70% of the residue initially present in the mash. Triglyceride accumulation in the liver was the most sensitive sign of chronic poisoning with carbon tetrachloride and was apparent after only 6 wk of treatment with a daily dose of about 1% of the LD50. Ethylene dichloride caused only a slight increase in liver fat at very high doses. Carbon tetrachloride and ethylene dichloride were each administered to rats for 2 yr in fumigated mash at levels below the obviously harmful ones. Growth, fertility, reproduction and biochemical tests were used as criteria for establishing the no-effect levels. On the basis of these data, acceptable daily intakes of 10 mg/kg body weight for carbon tetrachloride and 25 mg/kg for ethylene dichloride are proposed. The respective tolerances are 100 and 250 ppm. The proposed tolerances in human food are discussed. © 1976 Pergamon Press.
Note:
Related Files :
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More details
DOI :
10.1016/S0015-6264(76)80252-0
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
28611
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:40
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Scientific Publication
Tolerance and acceptable daily intake of chlorinated fumigants in the rat diet
14


Bondi, A., Faculty of Agriculture, Rehovot, Israel
Herzberg, M., Ichilov Hospital, Tel Aviv, Israel

Tolerance and acceptable daily intake of chlorinated fumigants in the rat diet
Long-term trials were carried out with rats fed mash fumigated with carbon tetrachloride or ethylene dichloride (1,2-dichloroethane). The difficulty of maintaining a constant residual level of fumigant in the feed was overcome by adopting suitable storage and feeding procedures. The amounts of fumigant actually consumed accounted for 60-70% of the residue initially present in the mash. Triglyceride accumulation in the liver was the most sensitive sign of chronic poisoning with carbon tetrachloride and was apparent after only 6 wk of treatment with a daily dose of about 1% of the LD50. Ethylene dichloride caused only a slight increase in liver fat at very high doses. Carbon tetrachloride and ethylene dichloride were each administered to rats for 2 yr in fumigated mash at levels below the obviously harmful ones. Growth, fertility, reproduction and biochemical tests were used as criteria for establishing the no-effect levels. On the basis of these data, acceptable daily intakes of 10 mg/kg body weight for carbon tetrachloride and 25 mg/kg for ethylene dichloride are proposed. The respective tolerances are 100 and 250 ppm. The proposed tolerances in human food are discussed. © 1976 Pergamon Press.
Scientific Publication
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