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An MspI polymorphism at the bovine growth hormone (bGH) gene is linked to a locus affecting milk protein percentage
Year:
1999
Source of publication :
Animal Genetics
Authors :
Weller, Joel Ira
;
.
Volume :
30
Co-Authors:
Lagziel, A., Department of Genetics, Hebrew University of Jerusalem, 91904 Jerusalem, Israel
Lipkin, E., Department of Genetics, Hebrew University of Jerusalem, 91904 Jerusalem, Israel
Ezra, E., Israel Cattle Breeders Association, 38900 Caesaria Industrial Park, Israel
Soller, M., Department of Genetics, Hebrew University of Jerusalem, 91904 Jerusalem, Israel
Weller, J.I., Institute of Animal Sciences, Agricultural Research Organization, 50250 Bet Dagan, Israel
Facilitators :
From page:
296
To page:
299
(
Total pages:
4
)
Abstract:
SSCP analysis of the bovine growth hormone (bGH) gene in Israel Holstein dairy cattle uncovered five intragenic haplotypes, denoted A to E. Of these, Haplotype E differed from the others at six fragments; one of which corresponded to the polymorphic MspI site in intron III, at which haplotype E carried the disabled MspI (-) allele, haplotype E was observed in a single sire only, carrying haplotype A as the second bGH allele. In 523 daughters of this sire genotyped for the MspI polymorphism, heterozygous (+/-) as compared to homozygous (+/+) daughters, showed a significant increasing effect on protein percentage and kg protein per year; and a decreasing effect (P < 0.10) on milk somatic cell counts (MSSC). None of the daughters were homozygous (-/-), indicating that the frequency of this allele in the general population was essentially zero. Calculated skewness (g1) values for the two daughter groups differed significantly with (+/-) daughters showing negative skewness (in the direction of lower protein percentage), and (+/+) daughters positive skewness (in the direction of higher protein percentage). The direction of skewness in each group is indicative of the presence of a QTL having an increasing effect on milk protein percentage in coupling linkage with the MspI (-) allele in this sire, but at some distance from it. Maximum likelihood estimates of the proportion of recombination (r) between the putative QTL and bGH, and the allele substitution effect at the QTL (d), were r = 0.33, a = 0.07% protein, with standard errors 0.058 and 0.009% protein, respectively.
Note:
Related Files :
Animals
Base Sequence
cattle
Female
genetic linkage
Holstein
Male
Milk protein percentage
MspI polymorphism
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Related Content
More details
DOI :
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
28640
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:40
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Scientific Publication
An MspI polymorphism at the bovine growth hormone (bGH) gene is linked to a locus affecting milk protein percentage
30
Lagziel, A., Department of Genetics, Hebrew University of Jerusalem, 91904 Jerusalem, Israel
Lipkin, E., Department of Genetics, Hebrew University of Jerusalem, 91904 Jerusalem, Israel
Ezra, E., Israel Cattle Breeders Association, 38900 Caesaria Industrial Park, Israel
Soller, M., Department of Genetics, Hebrew University of Jerusalem, 91904 Jerusalem, Israel
Weller, J.I., Institute of Animal Sciences, Agricultural Research Organization, 50250 Bet Dagan, Israel
An MspI polymorphism at the bovine growth hormone (bGH) gene is linked to a locus affecting milk protein percentage
SSCP analysis of the bovine growth hormone (bGH) gene in Israel Holstein dairy cattle uncovered five intragenic haplotypes, denoted A to E. Of these, Haplotype E differed from the others at six fragments; one of which corresponded to the polymorphic MspI site in intron III, at which haplotype E carried the disabled MspI (-) allele, haplotype E was observed in a single sire only, carrying haplotype A as the second bGH allele. In 523 daughters of this sire genotyped for the MspI polymorphism, heterozygous (+/-) as compared to homozygous (+/+) daughters, showed a significant increasing effect on protein percentage and kg protein per year; and a decreasing effect (P < 0.10) on milk somatic cell counts (MSSC). None of the daughters were homozygous (-/-), indicating that the frequency of this allele in the general population was essentially zero. Calculated skewness (g1) values for the two daughter groups differed significantly with (+/-) daughters showing negative skewness (in the direction of lower protein percentage), and (+/+) daughters positive skewness (in the direction of higher protein percentage). The direction of skewness in each group is indicative of the presence of a QTL having an increasing effect on milk protein percentage in coupling linkage with the MspI (-) allele in this sire, but at some distance from it. Maximum likelihood estimates of the proportion of recombination (r) between the putative QTL and bGH, and the allele substitution effect at the QTL (d), were r = 0.33, a = 0.07% protein, with standard errors 0.058 and 0.009% protein, respectively.
Scientific Publication
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