נגישות
menu      
Advanced Search
Syntax
Search...
Volcani treasures
About
Terms of use
Manage
Community:
אסיף מאגר המחקר החקלאי
Powered by ClearMash Solutions Ltd -
GC/CI/MS analysis of aldicarb, butocarboxime, and their metabolites
Year:
1983
Source of publication :
Journal of Chromatographic Science
Authors :
Aharonson, Nadav
;
.
Muszkat, Lea
;
.
Volume :
21
Co-Authors:
Muszkat, L., Pestic. Chem. Resid. Res. Lab., Agric. Res. Organ., Volcani Cent. Bet Dagan, Israel
Aharonson, N., Pestic. Chem. Resid. Res. Lab., Agric. Res. Organ., Volcani Cent. Bet Dagan, Israel
Facilitators :
From page:
411
To page:
414
(
Total pages:
4
)
Abstract:
A direct GC/MS determination of aldicarb [2-methyl-2-(methylthio)propionaldehyde o-(methyl carbamoyl) oxime], of its structural isomer butocarboxime [2-methylthio-o-(N-methyl carbamoyl) butanone-3-oxime], and of their toxic sulfoxide and sulfone metabolites is developed. Mild GC conditions using a 2% OV-17 (phenyl-methyl silicone polymer) liquid phase column provide the lowest extent of degradation. The CI/MS of the directly introduced molecules is compared to their GC/CI/MS. Butocarboxime is analyzed intact whereas its metabolites, as well as aldicarb and its sulfone derivative, undergo an on-column dehydration. The intact carbon skeleton is maintained in this process, as evidenced by the [M-18]+ fragment observed in the isobutane-CI mass spectra. Aldicarb sulfoxide, the more labile molecule in these series, degrades on-column to the corresponding nitrile. Typical fragmentation patterns are observed in the GC/MS analysis which allow distinction between the two series of isomers.A direct GC/MS determination of aldicarb left bracket 2-methyl-2-(methylthio)propionaldehyde o-(methyl carbamoyl) oxime right bracket , of its structural isomer butocarboxime left bracket 2-methylthio-o-(N-methyl carbamoyl) butanone-3-oxime right bracket , and of their toxic sulfoxide and sulfone metabolites is developed. Mild GC conditions using a 2% OV-17 (phenyl-methyl silicone polymer) liquid phase column provide the lowest extent of degradation. The CI/MS of the directly introduced molecules is compared to their GC/CI/MS. Butocarboxime is analyzed intact whereas its metabolites, as well as aldicarb and its sulfone derivative, undergo an on-column dehydration. The intact carbon skeleton is maintained in this process, as evidenced by the left bracket M-18 right bracket ** plus fragment observed in the isobutane-Cl mass spectra.
Note:
Related Files :
Aldicarb
butocarboxime
Gas Chromatography
mass spectrometry
metabolite
methodology
nonhuman
pesticides
theoretical study
Show More
Related Content
More details
DOI :
Article number:
Affiliations:
Database:
Scopus
Publication Type:
Language:
English
Editors' remarks:
ID:
28690
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:41
You may also be interested in
Scientific Publication
GC/CI/MS analysis of aldicarb, butocarboxime, and their metabolites
21
Muszkat, L., Pestic. Chem. Resid. Res. Lab., Agric. Res. Organ., Volcani Cent. Bet Dagan, Israel
Aharonson, N., Pestic. Chem. Resid. Res. Lab., Agric. Res. Organ., Volcani Cent. Bet Dagan, Israel
GC/CI/MS analysis of aldicarb, butocarboxime, and their metabolites
A direct GC/MS determination of aldicarb [2-methyl-2-(methylthio)propionaldehyde o-(methyl carbamoyl) oxime], of its structural isomer butocarboxime [2-methylthio-o-(N-methyl carbamoyl) butanone-3-oxime], and of their toxic sulfoxide and sulfone metabolites is developed. Mild GC conditions using a 2% OV-17 (phenyl-methyl silicone polymer) liquid phase column provide the lowest extent of degradation. The CI/MS of the directly introduced molecules is compared to their GC/CI/MS. Butocarboxime is analyzed intact whereas its metabolites, as well as aldicarb and its sulfone derivative, undergo an on-column dehydration. The intact carbon skeleton is maintained in this process, as evidenced by the [M-18]+ fragment observed in the isobutane-CI mass spectra. Aldicarb sulfoxide, the more labile molecule in these series, degrades on-column to the corresponding nitrile. Typical fragmentation patterns are observed in the GC/MS analysis which allow distinction between the two series of isomers.A direct GC/MS determination of aldicarb left bracket 2-methyl-2-(methylthio)propionaldehyde o-(methyl carbamoyl) oxime right bracket , of its structural isomer butocarboxime left bracket 2-methylthio-o-(N-methyl carbamoyl) butanone-3-oxime right bracket , and of their toxic sulfoxide and sulfone metabolites is developed. Mild GC conditions using a 2% OV-17 (phenyl-methyl silicone polymer) liquid phase column provide the lowest extent of degradation. The CI/MS of the directly introduced molecules is compared to their GC/CI/MS. Butocarboxime is analyzed intact whereas its metabolites, as well as aldicarb and its sulfone derivative, undergo an on-column dehydration. The intact carbon skeleton is maintained in this process, as evidenced by the left bracket M-18 right bracket ** plus fragment observed in the isobutane-Cl mass spectra.
Scientific Publication
You may also be interested in