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Herpes simplex virus DNA polymerase, thymidine kinase and deoxyribonuclease activities in cells infected with wild type, ultraviolet-irradiated and defective virus
Year:
1979
Source of publication :
Archives of Virology
Authors :
Chejanovsky, Nor
;
.
Volume :
62
Co-Authors:
Becker, Y., Laboratory for Molecular Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Gutter, B., Laboratory for Molecular Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Cohen, Y., Laboratory for Molecular Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Chejanovsky, N., Laboratory for Molecular Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Rabkin, S., Laboratory for Molecular Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Fridlender, B., Laboratory for Molecular Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Facilitators :
From page:
163
To page:
174
(
Total pages:
12
)
Abstract:
The DNA polymerase, thymidine kinase and deoxyribonuclease activities were studied in cells infected with wild type (wt), ultraviolet (UV)-irradiated and defective herpes simplex virus type 1. All three enzymatic activities were expressed in cells infected with wt virus. In cells infected with UV-irradiated virus, the thymidine kinase and deoxyribonuclease activities were inhibited and the DNA polymerase activity was markedly suppressed. In cells producing defective virus, there was thymidine kinase activity, but the viral deoxyribonuclease activity was considerably reduced. The DNA polymerase activity was fully expressed in cells producing defective virus at passage level 5, but at passage level 6, the activity of the viral DNA polymerase declined. © 1979 Springer-Verlag.
Note:
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More details
DOI :
10.1007/BF01317549
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
28707
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:41
Scientific Publication
Herpes simplex virus DNA polymerase, thymidine kinase and deoxyribonuclease activities in cells infected with wild type, ultraviolet-irradiated and defective virus
62
Becker, Y., Laboratory for Molecular Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Gutter, B., Laboratory for Molecular Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Cohen, Y., Laboratory for Molecular Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Chejanovsky, N., Laboratory for Molecular Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Rabkin, S., Laboratory for Molecular Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Fridlender, B., Laboratory for Molecular Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Herpes simplex virus DNA polymerase, thymidine kinase and deoxyribonuclease activities in cells infected with wild type, ultraviolet-irradiated and defective virus
The DNA polymerase, thymidine kinase and deoxyribonuclease activities were studied in cells infected with wild type (wt), ultraviolet (UV)-irradiated and defective herpes simplex virus type 1. All three enzymatic activities were expressed in cells infected with wt virus. In cells infected with UV-irradiated virus, the thymidine kinase and deoxyribonuclease activities were inhibited and the DNA polymerase activity was markedly suppressed. In cells producing defective virus, there was thymidine kinase activity, but the viral deoxyribonuclease activity was considerably reduced. The DNA polymerase activity was fully expressed in cells producing defective virus at passage level 5, but at passage level 6, the activity of the viral DNA polymerase declined. © 1979 Springer-Verlag.
Scientific Publication
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