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Preparation of diastereomerically pure immunologically active carbocyclic nor-muramyldipeptide analogues
Year:
1992
Source of publication :
Tetrahedron
Authors :
Hönig, Helmut
;
.
Volume :
48
Co-Authors:
Kikelj, D., University of Ljubljana, Faculty of Natural Sciences and Technology, Department of Pharmacy, Aškerčeva 9, 61000 Ljubljana, Slovenia
Kidrič, J., Boris Kidrič Institute of Chemistry, Hajdrihova 19, 61000 Ljubljana, Slovenia
Pristovšek, P., Boris Kidrič Institute of Chemistry, Hajdrihova 19, 61000 Ljubljana, Slovenia
Pečar, S., University of Ljubljana, Faculty of Natural Sciences and Technology, Department of Pharmacy, Aškerčeva 9, 61000 Ljubljana, Slovenia
Urleb, U., University of Ljubljana, Faculty of Natural Sciences and Technology, Department of Pharmacy, Aškerčeva 9, 61000 Ljubljana, Slovenia
Krbavčič, A., University of Ljubljana, Faculty of Natural Sciences and Technology, Department of Pharmacy, Aškerčeva 9, 61000 Ljubljana, Slovenia
Hönig, H., Technische Universität Graz, Institut für Organische Chemie, Stremayrgasse 16, A-8010 Graz, Austria
Facilitators :
From page:
5915
To page:
5932
(
Total pages:
18
)
Abstract:
The preparation of diastereomerically pure immunologically active carbocyclic nor-muramyldipeptide analogues (1′R,2′R)-/(1′S,2′S)-N-[2-(2′-acetylamino-cyclohexyloxy)acetyl]-L-alanyl-D-isoglutamine and (1′R,2′R)-/(1′S,2′S)-N-]2-(2′-acetylaminocyclohexyloxy)acetyl]-L-alanyl-D-glutamic acid is described. The title compounds were synthesized using two independent synthetic routes from racemic trans-2-azidocyclohexanol and (1R,2R)-/(1S,2S)-2-aminocyclohexanol, respectively. © 1992.
Note:
Related Files :
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drug structure
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More details
DOI :
10.1016/S0040-4020(01)90182-6
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
28882
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:42
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Scientific Publication
Preparation of diastereomerically pure immunologically active carbocyclic nor-muramyldipeptide analogues
48
Kikelj, D., University of Ljubljana, Faculty of Natural Sciences and Technology, Department of Pharmacy, Aškerčeva 9, 61000 Ljubljana, Slovenia
Kidrič, J., Boris Kidrič Institute of Chemistry, Hajdrihova 19, 61000 Ljubljana, Slovenia
Pristovšek, P., Boris Kidrič Institute of Chemistry, Hajdrihova 19, 61000 Ljubljana, Slovenia
Pečar, S., University of Ljubljana, Faculty of Natural Sciences and Technology, Department of Pharmacy, Aškerčeva 9, 61000 Ljubljana, Slovenia
Urleb, U., University of Ljubljana, Faculty of Natural Sciences and Technology, Department of Pharmacy, Aškerčeva 9, 61000 Ljubljana, Slovenia
Krbavčič, A., University of Ljubljana, Faculty of Natural Sciences and Technology, Department of Pharmacy, Aškerčeva 9, 61000 Ljubljana, Slovenia
Hönig, H., Technische Universität Graz, Institut für Organische Chemie, Stremayrgasse 16, A-8010 Graz, Austria
Preparation of diastereomerically pure immunologically active carbocyclic nor-muramyldipeptide analogues
The preparation of diastereomerically pure immunologically active carbocyclic nor-muramyldipeptide analogues (1′R,2′R)-/(1′S,2′S)-N-[2-(2′-acetylamino-cyclohexyloxy)acetyl]-L-alanyl-D-isoglutamine and (1′R,2′R)-/(1′S,2′S)-N-]2-(2′-acetylaminocyclohexyloxy)acetyl]-L-alanyl-D-glutamic acid is described. The title compounds were synthesized using two independent synthetic routes from racemic trans-2-azidocyclohexanol and (1R,2R)-/(1S,2S)-2-aminocyclohexanol, respectively. © 1992.
Scientific Publication
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