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Plant derived substances with anti-cancer activity: From folklore to practice
Year:
2015
Source of publication :
Frontiers in Plant Science
Authors :
Fridlender, Marcelo
;
.
Kapulnik, Yoram
;
.
Koltai, Hinanit
;
.
Volume :
6
Co-Authors:
Fridlender, M., Institute of Plant Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Kapulnik, Y., Institute of Plant Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Koltai, H., Institute of Plant Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Facilitators :
From page:
To page:
(
Total pages:
1
)
Abstract:
Plants have had an essential role in the folklore of ancient cultures. In addition to the use as food and spices, plants have also been utilized as medicines for over 5000 years. It is estimated that 70–95% of the population in developing countries continues to use traditional medicines even today. A new trend, that involved the isolation of plant active compounds begun during the early nineteenth century. This trend led to the discovery of different active compounds that are derived from plants. In the last decades, more and more new materials derived from plants have been authorized and subscribed as medicines, including those with anti-cancer activity. Cancer is among the leading causes of morbidity and mortality worldwide. The number of new cases is expected to rise by about 70% over the next two decades. Thus, there is a real need for new efficient anti-cancer drugs with reduced side effects, and plants are a promising source for such entities. Here we focus on some plant-derived substances exhibiting anti-cancer and chemoprevention activity, their mode of action and bioavailability. These include paclitaxel, curcumin, and cannabinoids. In addition, development and use of their synthetic analogs, and those of strigolactones, are discussed. Also discussed are commercial considerations and future prospects for development of plant derived substances with anti-cancer activity. © 2015 Fridlender, Kapulnik and Koltai.
Note:
Related Files :
Active compounds
Anti-cancer agents
cancer (disease)
Chemoprevention
Folklore
medicinal plants
plant
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Related Content
More details
DOI :
10.3389/fpls.2015.00799
Article number:
799
Affiliations:
Database:
Scopus
Publication Type:
Review
;
.
Language:
English
Editors' remarks:
ID:
28899
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:42
Scientific Publication
Plant derived substances with anti-cancer activity: From folklore to practice
6
Fridlender, M., Institute of Plant Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Kapulnik, Y., Institute of Plant Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Koltai, H., Institute of Plant Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Plant derived substances with anti-cancer activity: From folklore to practice
Plants have had an essential role in the folklore of ancient cultures. In addition to the use as food and spices, plants have also been utilized as medicines for over 5000 years. It is estimated that 70–95% of the population in developing countries continues to use traditional medicines even today. A new trend, that involved the isolation of plant active compounds begun during the early nineteenth century. This trend led to the discovery of different active compounds that are derived from plants. In the last decades, more and more new materials derived from plants have been authorized and subscribed as medicines, including those with anti-cancer activity. Cancer is among the leading causes of morbidity and mortality worldwide. The number of new cases is expected to rise by about 70% over the next two decades. Thus, there is a real need for new efficient anti-cancer drugs with reduced side effects, and plants are a promising source for such entities. Here we focus on some plant-derived substances exhibiting anti-cancer and chemoprevention activity, their mode of action and bioavailability. These include paclitaxel, curcumin, and cannabinoids. In addition, development and use of their synthetic analogs, and those of strigolactones, are discussed. Also discussed are commercial considerations and future prospects for development of plant derived substances with anti-cancer activity. © 2015 Fridlender, Kapulnik and Koltai.
Scientific Publication
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