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Induction of tibial dyschondroplasia in turkeys by tetramethylthiuram disulfide (Thiram)
Year:
2007
Source of publication :
Poultry Science
Authors :
Hasdai, Aharon
;
.
Monsonego-Ornan, Efrat
;
.
Volume :
86
Co-Authors:
Simsa, S., Faculty of Agricultural, Food and Environmental Quality Sciences, Department of Biochemistry and Nutrition, Hebrew University, Rehovot 76100, Israel
Hasdai, A., Institute of Animal Science, Volcani Center, Bet Dagan 50250, Israel
Dan, H., Faculty of Agricultural, Food and Environmental Quality Sciences, Department of Biochemistry and Nutrition, Hebrew University, Rehovot 76100, Israel
Ornan, E.M., Faculty of Agricultural, Food and Environmental Quality Sciences, Department of Biochemistry and Nutrition, Hebrew University, Rehovot 76100, Israel, Institute of Animal Science, Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
1766
To page:
1771
(
Total pages:
6
)
Abstract:
Tibial dyschondroplasia (TD) is a prevalent skeletal abnormality associated with rapid growth rate in many avian species; it causes enormous economic losses and is an animal welfare problem. Tibial dyschondroplasia is characterized by the presence of a nonvascularized, nonmineralized lesion that extends from the epiphyseal growth plate into the metaphysis of the proximal tibiotarsal bones. The mechanisms underlying TD development are not known, although they have been extensively studied in broilers using different induction models. However, an effective model for TD induction in turkeys has never been described. The objective of this study was to establish such a model by using tetramethylthiuram disulfide (thiram), an agent that is frequently used in broilers to induce TD. We found that dramatically longer exposures to much higher concentrations of thiram were required to induce TD in turkeys vs. broilers. In contrast to broilers, in which 50 mg/kg of thiram induces a high incidence of severe TD within 10 d, in turkeys, an exposure to 400 mg/kg of thiram for 11 wk was necessary for the development of severe TD lesions. These results show different mechanisms for TD induction in these 2 closely related species, suggesting differences in TD etiology between them. ©2007 Poultry Science Association Inc.
Note:
Related Files :
Animal
animal disease
Animals
Aves
Chickens
drug effect
Growth plate
hindlimb
Osteochondrodysplasias
Poultry Diseases
Show More
Related Content
More details
DOI :
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
29026
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:43
Scientific Publication
Induction of tibial dyschondroplasia in turkeys by tetramethylthiuram disulfide (Thiram)
86
Simsa, S., Faculty of Agricultural, Food and Environmental Quality Sciences, Department of Biochemistry and Nutrition, Hebrew University, Rehovot 76100, Israel
Hasdai, A., Institute of Animal Science, Volcani Center, Bet Dagan 50250, Israel
Dan, H., Faculty of Agricultural, Food and Environmental Quality Sciences, Department of Biochemistry and Nutrition, Hebrew University, Rehovot 76100, Israel
Ornan, E.M., Faculty of Agricultural, Food and Environmental Quality Sciences, Department of Biochemistry and Nutrition, Hebrew University, Rehovot 76100, Israel, Institute of Animal Science, Volcani Center, Bet Dagan 50250, Israel
Induction of tibial dyschondroplasia in turkeys by tetramethylthiuram disulfide (Thiram)
Tibial dyschondroplasia (TD) is a prevalent skeletal abnormality associated with rapid growth rate in many avian species; it causes enormous economic losses and is an animal welfare problem. Tibial dyschondroplasia is characterized by the presence of a nonvascularized, nonmineralized lesion that extends from the epiphyseal growth plate into the metaphysis of the proximal tibiotarsal bones. The mechanisms underlying TD development are not known, although they have been extensively studied in broilers using different induction models. However, an effective model for TD induction in turkeys has never been described. The objective of this study was to establish such a model by using tetramethylthiuram disulfide (thiram), an agent that is frequently used in broilers to induce TD. We found that dramatically longer exposures to much higher concentrations of thiram were required to induce TD in turkeys vs. broilers. In contrast to broilers, in which 50 mg/kg of thiram induces a high incidence of severe TD within 10 d, in turkeys, an exposure to 400 mg/kg of thiram for 11 wk was necessary for the development of severe TD lesions. These results show different mechanisms for TD induction in these 2 closely related species, suggesting differences in TD etiology between them. ©2007 Poultry Science Association Inc.
Scientific Publication
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