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Halevy, O., Department of Animal Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel, Dept. of Animal Sciences, Hebrew Univ. of Jerusalem, PO Box 12, Rehovot 76100, Israel
Krispin, A., Department of Animal Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel
Leshem, Y., Department of Animal Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel
McMurtry, J.P., Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Yahav, S., United States Department of Agriculture, Growth Biology Laboratory, Agricultural Research Service, Beltsville, MD 20705, United States
Exposure of young chicks to thermal conditioning (TC; i.e., 37°C for 24 h) resulted in significantly improved body and muscle growth at a later age. We hypothesized that TC causes an increase in satellite cell proliferation, necessary for further muscle hypertrophy. An immediate increase was observed in satellite cell DNA synthesis in culture and in vivo in response to TC of 3-day-old chicks to levels that were significantly higher than those of control chicks. This was accompanied by a marked induction of insulin-like growth factor-I (IFG-I), but not hepatocyte growth factor in the breast muscle. No significant difference between treatments in plasma IGF-I levels was observed. A marked elevation in muscle regulatory factors on day 5, followed by a decline in cell proliferation on day 6 together with continuous high levels of IGF-I in the TC chick muscle may indicate accelerated cell differentiation. These data suggest a central role for IGF-I in the immediate stimulation of satellite cell myogenic processes in response to heat exposure.
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Early-age heat exposure affects skeletal muscle satellite cell proliferation and differentiation in chicks
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Halevy, O., Department of Animal Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel, Dept. of Animal Sciences, Hebrew Univ. of Jerusalem, PO Box 12, Rehovot 76100, Israel
Krispin, A., Department of Animal Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel
Leshem, Y., Department of Animal Sciences, Hebrew University of Jerusalem, Rehovot 76100, Israel
McMurtry, J.P., Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Yahav, S., United States Department of Agriculture, Growth Biology Laboratory, Agricultural Research Service, Beltsville, MD 20705, United States
Early-age heat exposure affects skeletal muscle satellite cell proliferation and differentiation in chicks
Exposure of young chicks to thermal conditioning (TC; i.e., 37°C for 24 h) resulted in significantly improved body and muscle growth at a later age. We hypothesized that TC causes an increase in satellite cell proliferation, necessary for further muscle hypertrophy. An immediate increase was observed in satellite cell DNA synthesis in culture and in vivo in response to TC of 3-day-old chicks to levels that were significantly higher than those of control chicks. This was accompanied by a marked induction of insulin-like growth factor-I (IFG-I), but not hepatocyte growth factor in the breast muscle. No significant difference between treatments in plasma IGF-I levels was observed. A marked elevation in muscle regulatory factors on day 5, followed by a decline in cell proliferation on day 6 together with continuous high levels of IGF-I in the TC chick muscle may indicate accelerated cell differentiation. These data suggest a central role for IGF-I in the immediate stimulation of satellite cell myogenic processes in response to heat exposure.
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