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Ectothermy and endothermy: Evolutionary perspectives of thermoprotection by HSPs
Year:
2005
Source of publication :
Journal of Experimental Biology
Authors :
Shabtay, Ariel
;
.
Volume :
208
Co-Authors:
Shabtay, A., Department of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel
Arad, Z., Department of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel
Facilitators :
From page:
2773
To page:
2781
(
Total pages:
9
)
Abstract:
Living organisms respond to heat exposure by selectively expressing heat shock proteins (HSPs). Accumulation of HSPs confers thermotolerance in cell cultures and in ectotherms and is an important component of the heat shock response. This response, however, has not been directly examined in relation to different 'thermal states', namely ectothermy vs endothermy. By using avian development as a model system for transition from ectothermy to endothermy, we show that, in contrast to the ectothermic state, in the endothermic state the organism is more resistant to heat but relies less on HSPs as a first-line thermoprotective mechanism. Moreover, intraspecific, real-time, in vivo measurements in genetically diverse fowl strains relate improvement of thermoresistance in endotherms to improved body temperature (Tb) regulation, with a concomitant delay in the expression of HSPs. The time course of this delay and the Tb at which it occurs imply that the ontogenetic and evolutionary pathways leading to improved thermoresistance may have followed two, apparently non-related, parallel routes - cellular and peripheral (non-cellular). In search of other cellular components that differentially participate in the heat shock response, we revealed a significant expression of fatty acid synthase (FAS) in heat-exposed endotherms but not in ectotherms.
Note:
Related Files :
Animal
Animals
Electrophoresis, Polyacrylamide Gel
Evolution
Fatty Acid Synthetase Complex
Heat-Shock Proteins
Hsp
metabolism
Show More
Related Content
More details
DOI :
10.1242/jeb.01705
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
29184
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:44
Scientific Publication
Ectothermy and endothermy: Evolutionary perspectives of thermoprotection by HSPs
208
Shabtay, A., Department of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel
Arad, Z., Department of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel
Ectothermy and endothermy: Evolutionary perspectives of thermoprotection by HSPs
Living organisms respond to heat exposure by selectively expressing heat shock proteins (HSPs). Accumulation of HSPs confers thermotolerance in cell cultures and in ectotherms and is an important component of the heat shock response. This response, however, has not been directly examined in relation to different 'thermal states', namely ectothermy vs endothermy. By using avian development as a model system for transition from ectothermy to endothermy, we show that, in contrast to the ectothermic state, in the endothermic state the organism is more resistant to heat but relies less on HSPs as a first-line thermoprotective mechanism. Moreover, intraspecific, real-time, in vivo measurements in genetically diverse fowl strains relate improvement of thermoresistance in endotherms to improved body temperature (Tb) regulation, with a concomitant delay in the expression of HSPs. The time course of this delay and the Tb at which it occurs imply that the ontogenetic and evolutionary pathways leading to improved thermoresistance may have followed two, apparently non-related, parallel routes - cellular and peripheral (non-cellular). In search of other cellular components that differentially participate in the heat shock response, we revealed a significant expression of fatty acid synthase (FAS) in heat-exposed endotherms but not in ectotherms.
Scientific Publication
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