נגישות
menu      
Advanced Search
Syntax
Search...
Volcani treasures
About
Terms of use
Manage
Community:
אסיף מאגר המחקר החקלאי
Powered by ClearMash Solutions Ltd -
Computer assisted design of a theophylline dosing regimen in acute bronchospasm: Serum concentrations and clinical outcome
Year:
1992
Authors :
Ezra, David
;
.
Volume :
43
Co-Authors:
Verner, D., Division of Clinical Pharmacology and Department of Medicine A, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Seligmann, H., Division of Clinical Pharmacology and Department of Medicine A, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Platt, S., Division of Clinical Pharmacology and Department of Medicine A, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Dany, S., Division of Clinical Pharmacology and Department of Medicine A, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Almog, S., Division of Clinical Pharmacology and Department of Medicine A, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Zulty, L., Division of Clinical Pharmacology and Department of Medicine A, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Halkin, H., Division of Clinical Pharmacology and Department of Medicine A, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Ezra, D., Division of Clinical Pharmacology and Department of Medicine A, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Division of Clinical Pharmacology, Sheba Medical Center, Tel-Hashomer, Ramat-Gab, 52621, Israel
Facilitators :
From page:
29
To page:
33
(
Total pages:
5
)
Abstract:
The effect of intravenous theophylline on the outcome of inhospital treatment of acute bronchospasm has been assessed, comparing the results achieved by computer-assisted dosing, designed to achieve and maintain a serum theophylline level of 16 μg · ml-1 (10 patients) with those of unaided physicians (15 control patients). The outcome measures compared were clinical improvement, peak expiratory flow rate and serum theophylline concentration. Loading doses of theophylline in the control and computer groups were: 167 and 437 mg, respectively. Initial serum theophylline concentrations, measured 20 min after the loading dose, were 13.6 and 17.0 μg · ml-1 in the control and computer groups, respectively. In patients who had not received theophylline prior to admission, loading doses and initial concentrations were: 200 mg and 9.4 μg · ml-1 in the control group (n = 5) versus 613 mg and 15.7 μg · ml-1 in the computer group (n = 4), respectively. During maintenance therapy, serum theophylline concentrations were kept in the therapeutic range (10-20 μg · ml-1) throughout 51 % and 77 % of the hospitalisation period, in the control and computer groups, respectively. There were no differences between the two groups in the rate or extent of clinical improvement or in change in peak expiratory flow rate. The computer assisted theophylline dosing regimen outperformed that of the unaided physicians in achieving and maintaining therapeutic serum theophylline concentrations in acute bronchospasm. There was no correlation between clinical outcome and serum theophylline concentration, but this may have been due to the small sample size and modest difference in serum theophylline between the two groups. The findings serve as an additional argument in favour of the trend away from reliance on theophylline as first line therapy in acute bronchospasm. © 1992 Springer-Verlag.
Note:
Related Files :
Acute Disease
adult
aged
bronchospasm
computer program
Female
intravenous drug administration
Male
Show More
Related Content
More details
DOI :
10.1007/BF02280750
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
29253
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:45
Scientific Publication
Computer assisted design of a theophylline dosing regimen in acute bronchospasm: Serum concentrations and clinical outcome
43
Verner, D., Division of Clinical Pharmacology and Department of Medicine A, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Seligmann, H., Division of Clinical Pharmacology and Department of Medicine A, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Platt, S., Division of Clinical Pharmacology and Department of Medicine A, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Dany, S., Division of Clinical Pharmacology and Department of Medicine A, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Almog, S., Division of Clinical Pharmacology and Department of Medicine A, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Zulty, L., Division of Clinical Pharmacology and Department of Medicine A, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Halkin, H., Division of Clinical Pharmacology and Department of Medicine A, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Ezra, D., Division of Clinical Pharmacology and Department of Medicine A, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Division of Clinical Pharmacology, Sheba Medical Center, Tel-Hashomer, Ramat-Gab, 52621, Israel
Computer assisted design of a theophylline dosing regimen in acute bronchospasm: Serum concentrations and clinical outcome
The effect of intravenous theophylline on the outcome of inhospital treatment of acute bronchospasm has been assessed, comparing the results achieved by computer-assisted dosing, designed to achieve and maintain a serum theophylline level of 16 μg · ml-1 (10 patients) with those of unaided physicians (15 control patients). The outcome measures compared were clinical improvement, peak expiratory flow rate and serum theophylline concentration. Loading doses of theophylline in the control and computer groups were: 167 and 437 mg, respectively. Initial serum theophylline concentrations, measured 20 min after the loading dose, were 13.6 and 17.0 μg · ml-1 in the control and computer groups, respectively. In patients who had not received theophylline prior to admission, loading doses and initial concentrations were: 200 mg and 9.4 μg · ml-1 in the control group (n = 5) versus 613 mg and 15.7 μg · ml-1 in the computer group (n = 4), respectively. During maintenance therapy, serum theophylline concentrations were kept in the therapeutic range (10-20 μg · ml-1) throughout 51 % and 77 % of the hospitalisation period, in the control and computer groups, respectively. There were no differences between the two groups in the rate or extent of clinical improvement or in change in peak expiratory flow rate. The computer assisted theophylline dosing regimen outperformed that of the unaided physicians in achieving and maintaining therapeutic serum theophylline concentrations in acute bronchospasm. There was no correlation between clinical outcome and serum theophylline concentration, but this may have been due to the small sample size and modest difference in serum theophylline between the two groups. The findings serve as an additional argument in favour of the trend away from reliance on theophylline as first line therapy in acute bronchospasm. © 1992 Springer-Verlag.
Scientific Publication
You may also be interested in