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Multiple quantitative trait locus analysis of bovine chromosome 6 in the Israeli Holstein population by a daughter design
Year:
2001
Source of publication :
Genetics (source)
Authors :
Kliger, David
;
.
Ron, Micha
;
.
Seroussi, Eyal
;
.
Weller, Joel Ira
;
.
Volume :
159
Co-Authors:
Ron, M., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Kliger, D., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Feldmesser, E., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Seroussi, E., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Ezra, E., Israel Cattle Breeders Association, Caesaria 38900, Israel
Weller, J.I., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel, Institute of Animal Sciences, ARO, Volcani Ctr., P.O. Box 6, Bet Dagan 50250, Israel
Facilitators :
From page:
727
To page:
735
(
Total pages:
9
)
Abstract:
Nine Israeli Holstein sire families with 2978 daughters were analyzed for quantitative trait loci effects on chromosome 6 for five milk production traits by a daughter design. All animals were genotyped for 2 markers. The three families with significant effects were genotyped for up to 10 additional markers spanning positions 0-122 cM of BTA6. Two sires were segregating for a locus affecting protein and fat percentage near position 55 cM with an estimated substitution effect of 0.18% protein, which is equivalent to one phenotypic standard deviation. This locus was localized to a confidence interval of 4 cM. One of these sires was also heterozygous for a locus affecting milk, fat, and protein production near the centromere. The hypothesis of two segregating loci was verified by multiple regression analysis. A third sire was heterozygous for a locus affecting milk and protein percentage near the telomeric end of the chromosome. Possible candidates for the major quantitative gene near position 55 cM were determined by comparative mapping. IBSP and SSPI were used as anchors for the orthologous region on human chromosome 4. Twelve genes were detected within a 2-Mbp sequence. None of these genes have been previously associated with lactogenesis.
Note:
Related Files :
Animals
cattle
chromosome mapping
Female
genetic markers
Israel
Male
milk
phenotype
Show More
Related Content
More details
DOI :
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
29358
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:46
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Scientific Publication
Multiple quantitative trait locus analysis of bovine chromosome 6 in the Israeli Holstein population by a daughter design
159
Ron, M., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Kliger, D., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Feldmesser, E., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Seroussi, E., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel
Ezra, E., Israel Cattle Breeders Association, Caesaria 38900, Israel
Weller, J.I., Institute of Animal Sciences, ARO, Volcani Center, Bet Dagan 50250, Israel, Institute of Animal Sciences, ARO, Volcani Ctr., P.O. Box 6, Bet Dagan 50250, Israel
Multiple quantitative trait locus analysis of bovine chromosome 6 in the Israeli Holstein population by a daughter design
Nine Israeli Holstein sire families with 2978 daughters were analyzed for quantitative trait loci effects on chromosome 6 for five milk production traits by a daughter design. All animals were genotyped for 2 markers. The three families with significant effects were genotyped for up to 10 additional markers spanning positions 0-122 cM of BTA6. Two sires were segregating for a locus affecting protein and fat percentage near position 55 cM with an estimated substitution effect of 0.18% protein, which is equivalent to one phenotypic standard deviation. This locus was localized to a confidence interval of 4 cM. One of these sires was also heterozygous for a locus affecting milk, fat, and protein production near the centromere. The hypothesis of two segregating loci was verified by multiple regression analysis. A third sire was heterozygous for a locus affecting milk and protein percentage near the telomeric end of the chromosome. Possible candidates for the major quantitative gene near position 55 cM were determined by comparative mapping. IBSP and SSPI were used as anchors for the orthologous region on human chromosome 4. Twelve genes were detected within a 2-Mbp sequence. None of these genes have been previously associated with lactogenesis.
Scientific Publication
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