אסיף מאגר המחקר החקלאי

Membrane-disrupting properties of the steroidal glycoalkaloids solasonine and solamargine

Year:

1990

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Volume :

29

Co-Authors:

Roddick, J.G., Department of Biological Sciences, University of Exeter, Exeter, United Kingdom
Rijnenberg, A.L., Department of Biological Sciences, University of Exeter, Exeter, United Kingdom
Weissenberg, M., Department of Biological Sciences, University of Exeter, Exeter, United Kingdom, Department of Chemistry of Natural Products, A.R.O., The Volcani Center, P.O.B. 6, Bet Dagan, Israel

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Abstract:

The steroidal glycoalkaloid solamargine caused significant disruption of phosphatidylcholine/cholesterol liposomes at a concentration > 50 μM whereas the normally co-occurring glycoalkaloid solasonine was ineffective at up to 150 μM. In combination, the two compounds produced a marked synergism. Synergistic effects were also observed with certain combinations of these and potato glycoalkaloids, viz. solamargine and solanine and also solasonine and chaconine. With solamargine and chaconine the effect was additive while solasonine and solanine together caused no lysis. Solamargine also bound more effectively than solasonine to cholesterol in vitro, but there was no synergy between the glycoalkaloids in this action. Penicillium notatum-derived protoplasts and bovine erythrocytes were lysed by both solamargine and solasonine with solamargine being more disruptive in both systems and erythrocytes more susceptible. The two glycoalkaloids synergized in their effects on both protoplasts and erythrocytes. © 1990.

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