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Multiple specific contacts between a mammalian transcription factor and its cognate promoters
Year:
1984
Source of publication :
Nature
Authors :
Gidoni, David
;
.
Volume :
312
Co-Authors:
Gidoni, D., Department of Biochemistry, University of California, Berkeley, CA 94720, United States
Dynan, W.S., Department of Biochemistry, University of California, Berkeley, CA 94720, United States
Tjian, R., Department of Biochemistry, University of California, Berkeley, CA 94720, United States
Facilitators :
From page:
409
To page:
413
(
Total pages:
5
)
Abstract:
The human transcription factor Sp1 binds upstream of certain viral and cellular promoters and activates initiation of RNA synthesis from these promoters by RNA polymerase II. The Sp1 binding sites of both simian virus 40 and a related monkey promoter contain multiple copies of the sequence GGGCGG, three or four of these sequences forming close contacts with Sp1. The clustered contacts fall on one strand of the DNA and are arranged similarly in the major groove of the DNA helix in both promoters. © 1984 Nature Publishing Group.
Note:
Related Files :
Animal
Base Sequence
DNA protein complex
genetic transcription
HeLa cells
Heredity
Models, Molecular
Promoter Regions (Genetics)
Show More
Related Content
More details
DOI :
10.1038/312409a0
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
29717
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:49
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Scientific Publication
Multiple specific contacts between a mammalian transcription factor and its cognate promoters
312
Gidoni, D., Department of Biochemistry, University of California, Berkeley, CA 94720, United States
Dynan, W.S., Department of Biochemistry, University of California, Berkeley, CA 94720, United States
Tjian, R., Department of Biochemistry, University of California, Berkeley, CA 94720, United States
Multiple specific contacts between a mammalian transcription factor and its cognate promoters
The human transcription factor Sp1 binds upstream of certain viral and cellular promoters and activates initiation of RNA synthesis from these promoters by RNA polymerase II. The Sp1 binding sites of both simian virus 40 and a related monkey promoter contain multiple copies of the sequence GGGCGG, three or four of these sequences forming close contacts with Sp1. The clustered contacts fall on one strand of the DNA and are arranged similarly in the major groove of the DNA helix in both promoters. © 1984 Nature Publishing Group.
Scientific Publication
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