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Increased serum leptin and insulin concentrations in canine hypothyroidism
Year:
2010
Source of publication :
Veterinary Journal
Authors :
Shamay, Avi
;
.
Volume :
183
Co-Authors:
Mazaki-Tovi, M., Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel
Feuermann, Y., The Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Segev, G., Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel
Klement, E., Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel
Yas-Natan, E., Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel
Farkas, A., The American Medical Laboratories, Herzliya, Israel
Kol, A., Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel
Shamay, A., The Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Facilitators :
From page:
109
To page:
114
(
Total pages:
6
)
Abstract:
Serum concentrations of leptin and insulin were compared between gender-matched hypothyroid (n = 25) and healthy (n = 25) client-owned dogs within comparable age and body condition score (BCS) ranges. Fasted blood samples were collected from each dog and analysed for glucose, cholesterol, triglyceride, leptin and insulin concentrations. Leptin and insulin concentrations were significantly higher in the hypothyroid compared to normal dogs (P = 0.006 and P = 0.001, respectively) following adjustment for potential confounders. A nearly significant (P = 0.051) interaction with BCS was found in the association between hypothyroidism and leptin. Leptin concentrations were significantly higher in hypothyroid dogs compared to normal dogs, in separate analyses for BCS 6 (P = 0.036) and 7 (P = 0.049). There was no significant difference in glucose concentration between the hypothyroid and normal groups (P = 0.84) following adjustment for BCS. This study showed that canine hypothyroidism is associated with increased serum leptin and insulin concentrations, neither of which may be attributed to obesity alone. © 2008 Elsevier Ltd. All rights reserved.
Note:
Related Files :
animal experiment
Animals
cholesterol blood level
disease association
Dog Diseases
Female
Male
obesity
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More details
DOI :
10.1016/j.tvjl.2008.08.017
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
29931
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:50
Scientific Publication
Increased serum leptin and insulin concentrations in canine hypothyroidism
183
Mazaki-Tovi, M., Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel
Feuermann, Y., The Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Segev, G., Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel
Klement, E., Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel
Yas-Natan, E., Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel
Farkas, A., The American Medical Laboratories, Herzliya, Israel
Kol, A., Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel
Shamay, A., The Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Increased serum leptin and insulin concentrations in canine hypothyroidism
Serum concentrations of leptin and insulin were compared between gender-matched hypothyroid (n = 25) and healthy (n = 25) client-owned dogs within comparable age and body condition score (BCS) ranges. Fasted blood samples were collected from each dog and analysed for glucose, cholesterol, triglyceride, leptin and insulin concentrations. Leptin and insulin concentrations were significantly higher in the hypothyroid compared to normal dogs (P = 0.006 and P = 0.001, respectively) following adjustment for potential confounders. A nearly significant (P = 0.051) interaction with BCS was found in the association between hypothyroidism and leptin. Leptin concentrations were significantly higher in hypothyroid dogs compared to normal dogs, in separate analyses for BCS 6 (P = 0.036) and 7 (P = 0.049). There was no significant difference in glucose concentration between the hypothyroid and normal groups (P = 0.84) following adjustment for BCS. This study showed that canine hypothyroidism is associated with increased serum leptin and insulin concentrations, neither of which may be attributed to obesity alone. © 2008 Elsevier Ltd. All rights reserved.
Scientific Publication
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