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Discovery of a linear lead antagonist to the insect pheromone biosynthesis activating neuropeptide (PBAN)
Year:
2000
Source of publication :
peptides ( source)
Authors :
Altstein, Miriam
;
.
Ben-Aziz, Orna
;
.
Schaeffler, Irit
;
.
Volume :
21
Co-Authors:
Zeltser, I., Dept. of Organic Chemistry, Hebrew Univ. of Jerusalem, Jerusalem 91904, Israel
Gilon, C., Dept. of Organic Chemistry, Hebrew Univ. of Jerusalem, Jerusalem 91904, Israel
Ben-Aziz, O., Dept. of Entomology, Volcani Center, Bet Dagan 50250, Israel
Schefler, I., Dept. of Entomology, Volcani Center, Bet Dagan 50250, Israel
Altstein, M., Dept. of Entomology, Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
1457
To page:
1465
(
Total pages:
9
)
Abstract:
We report the discovery of a linear lead antagonist for the insect pheromone biosynthesis activating neuropeptide (PBAN) which inhibits sex pheromone biosynthesis in the female moth Heliothis peltigera. Two approaches have been used in attempting to convert PBAN agonists into antagonists. The first involved omission of the C-terminal amide and reduction of the sequence from the N-terminus in a linear library based on PBAN 1-33NH2. The second involved replacement of L amino-acids by the D hydrophobic amino acid D-Phe in a linear library based on PBAN28-33NH2. Screening of the two libraries for pheromonotropic antagonists resulted in the disclosure of one compound out of the D-Phe library (Arg-Tyr-Phe-D-Phe-Pro-Arg-Leu-NH2) which inhibited sex pheromone production by 79 and 64% at 100 pmol in two moth colonies and exhibited low agonistic activity. Omission of the C-terminal amide in PBAN 1-33NH2 and its shorter analogs did not lead to the discovery of an antagonistic compound. Copyright (C) 2000 Elsevier Science Inc.
Note:
Related Files :
Animal
animal experiment
biosynthesis
Female
Lepidoptera
Moths
neuropeptide
Peltigera
pheromones
Show More
Related Content
More details
DOI :
10.1016/S0196-9781(00)00298-9
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
29942
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:50
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Scientific Publication
Discovery of a linear lead antagonist to the insect pheromone biosynthesis activating neuropeptide (PBAN)
21
Zeltser, I., Dept. of Organic Chemistry, Hebrew Univ. of Jerusalem, Jerusalem 91904, Israel
Gilon, C., Dept. of Organic Chemistry, Hebrew Univ. of Jerusalem, Jerusalem 91904, Israel
Ben-Aziz, O., Dept. of Entomology, Volcani Center, Bet Dagan 50250, Israel
Schefler, I., Dept. of Entomology, Volcani Center, Bet Dagan 50250, Israel
Altstein, M., Dept. of Entomology, Volcani Center, Bet Dagan 50250, Israel
Discovery of a linear lead antagonist to the insect pheromone biosynthesis activating neuropeptide (PBAN)
We report the discovery of a linear lead antagonist for the insect pheromone biosynthesis activating neuropeptide (PBAN) which inhibits sex pheromone biosynthesis in the female moth Heliothis peltigera. Two approaches have been used in attempting to convert PBAN agonists into antagonists. The first involved omission of the C-terminal amide and reduction of the sequence from the N-terminus in a linear library based on PBAN 1-33NH2. The second involved replacement of L amino-acids by the D hydrophobic amino acid D-Phe in a linear library based on PBAN28-33NH2. Screening of the two libraries for pheromonotropic antagonists resulted in the disclosure of one compound out of the D-Phe library (Arg-Tyr-Phe-D-Phe-Pro-Arg-Leu-NH2) which inhibited sex pheromone production by 79 and 64% at 100 pmol in two moth colonies and exhibited low agonistic activity. Omission of the C-terminal amide in PBAN 1-33NH2 and its shorter analogs did not lead to the discovery of an antagonistic compound. Copyright (C) 2000 Elsevier Science Inc.
Scientific Publication
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