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Evidence for a major gene affecting the transition from normoglycaemia to hyperglycaemia in Psammomys obesus
Year:
2005
Source of publication :
Heredity
Authors :
Ben-Ari, Giora
;
.
Lavi, Uri
;
.
Volume :
95
Co-Authors:
Hillel, J., Robert H Smith Institute of Plant Sciences and Genetics, Hebrew University of Jerusalem, Rehovot 76100, Israel
Gefel, D., Department of Medicine-C, Barzilai Medical Center, Ashkelon 78306, Israel
Kalman, R., Authority for Research Animals, Hebrew University of Jerusalem, Israel
Ben-Ari, G., Robert H Smith Institute of Plant Sciences and Genetics, Hebrew University of Jerusalem, Rehovot 76100, Israel
David, L., Robert H Smith Institute of Plant Sciences and Genetics, Hebrew University of Jerusalem, Rehovot 76100, Israel
Orion, O., Institute of Evolution, University of Haifa, Mt. Carmel, Haifa 31905, Israel
Feldman, M.W., Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020, United States
Bar-On, H., Diabetes Research Center, Hadassah University Hospital, Jerusalem 91120, Israel
Blum, S., Robert H Smith Institute of Plant Sciences and Genetics, Hebrew University of Jerusalem, Rehovot 76100, Israel
Raz, I., Diabetes Research Center, Hadassah University Hospital, Jerusalem 91120, Israel
Schaap, T., Department of Human Genetics, Hadassah Medical Center, Jerusalem 91120, Israel
Shpirer, I., Pulmonary Institute, Assaf Harofeh Medical Center, PO Beer Yaacov, Zerifin 70300, Israel
Lavi, U., Institute of Horticulture, ARO-Volcani Center, PO Box 6, Bet-Dagan 50250, Israel
Shafrir, E., Diabetes Research Center, Hadassah University Hospital, Jerusalem 91120, Israel
Ziv, E., Diabetes Research Center, Hadassah University Hospital, Jerusalem 91120, Israel
Facilitators :
From page:
158
To page:
165
(
Total pages:
8
)
Abstract:
We investigated the mode of inheritance of nutritionally induced diabetes in the desert gerbil Psammomys obesus (sand rat), following transfer from low-energy (LE) to high-energy (HE) diet which induces hyperglycaemia. Psammomys selected for high or low blood glucose level were used as two parental lines. A first backcross generation (BC 1) was formed by crossing F 1 males with females of the diabetes-prone line. The resulting 232 BC 1 progeny were assessed for blood glucose. All progeny were weaned at 3 weeks of age (week 0), and their weekly assessment of blood glucose levels proceeded until week 9 after weaning, with all progeny maintained on HE diet. At weeks 1 to 9 post weaning, a clear bimodal distribution statistically different from unimodal distribution of blood glucose was observed, normoglycaemic and hyperglycaemic at a 1:1 ratio. This ratio is expected at the first backcross generation for traits controlled by a single dominant gene. From week 0 (prior to the transfer to HE diet) till week 8, the hyperglycaemic individuals were significantly heavier (4-17%) than the normoglycaemic ones. The bimodal blood glucose distribution in BC 1 generation, with about equal frequencies in each mode, strongly suggests that a single major gene affects the transition from normo- to hyperglycaemia. The wide range of blood glucose values among the hyperglycaemic individuals (180 to 500 mg/dl) indicates that several genes and environmental factors influence the extent of hyperglycaemia. The diabetes-resistant allele appears to be dominant; the estimate for dominance ratio is 0.97. © 2005 Nature Publishing Group All rights reserved.
Note:
Related Files :
Animal
Animals
Female
gene expression
Genetics
Male
metabolism
phenotype
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More details
DOI :
10.1038/sj.hdy.6800701
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
29972
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:51
Scientific Publication
Evidence for a major gene affecting the transition from normoglycaemia to hyperglycaemia in Psammomys obesus
95
Hillel, J., Robert H Smith Institute of Plant Sciences and Genetics, Hebrew University of Jerusalem, Rehovot 76100, Israel
Gefel, D., Department of Medicine-C, Barzilai Medical Center, Ashkelon 78306, Israel
Kalman, R., Authority for Research Animals, Hebrew University of Jerusalem, Israel
Ben-Ari, G., Robert H Smith Institute of Plant Sciences and Genetics, Hebrew University of Jerusalem, Rehovot 76100, Israel
David, L., Robert H Smith Institute of Plant Sciences and Genetics, Hebrew University of Jerusalem, Rehovot 76100, Israel
Orion, O., Institute of Evolution, University of Haifa, Mt. Carmel, Haifa 31905, Israel
Feldman, M.W., Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020, United States
Bar-On, H., Diabetes Research Center, Hadassah University Hospital, Jerusalem 91120, Israel
Blum, S., Robert H Smith Institute of Plant Sciences and Genetics, Hebrew University of Jerusalem, Rehovot 76100, Israel
Raz, I., Diabetes Research Center, Hadassah University Hospital, Jerusalem 91120, Israel
Schaap, T., Department of Human Genetics, Hadassah Medical Center, Jerusalem 91120, Israel
Shpirer, I., Pulmonary Institute, Assaf Harofeh Medical Center, PO Beer Yaacov, Zerifin 70300, Israel
Lavi, U., Institute of Horticulture, ARO-Volcani Center, PO Box 6, Bet-Dagan 50250, Israel
Shafrir, E., Diabetes Research Center, Hadassah University Hospital, Jerusalem 91120, Israel
Ziv, E., Diabetes Research Center, Hadassah University Hospital, Jerusalem 91120, Israel
Evidence for a major gene affecting the transition from normoglycaemia to hyperglycaemia in Psammomys obesus
We investigated the mode of inheritance of nutritionally induced diabetes in the desert gerbil Psammomys obesus (sand rat), following transfer from low-energy (LE) to high-energy (HE) diet which induces hyperglycaemia. Psammomys selected for high or low blood glucose level were used as two parental lines. A first backcross generation (BC 1) was formed by crossing F 1 males with females of the diabetes-prone line. The resulting 232 BC 1 progeny were assessed for blood glucose. All progeny were weaned at 3 weeks of age (week 0), and their weekly assessment of blood glucose levels proceeded until week 9 after weaning, with all progeny maintained on HE diet. At weeks 1 to 9 post weaning, a clear bimodal distribution statistically different from unimodal distribution of blood glucose was observed, normoglycaemic and hyperglycaemic at a 1:1 ratio. This ratio is expected at the first backcross generation for traits controlled by a single dominant gene. From week 0 (prior to the transfer to HE diet) till week 8, the hyperglycaemic individuals were significantly heavier (4-17%) than the normoglycaemic ones. The bimodal blood glucose distribution in BC 1 generation, with about equal frequencies in each mode, strongly suggests that a single major gene affects the transition from normo- to hyperglycaemia. The wide range of blood glucose values among the hyperglycaemic individuals (180 to 500 mg/dl) indicates that several genes and environmental factors influence the extent of hyperglycaemia. The diabetes-resistant allele appears to be dominant; the estimate for dominance ratio is 0.97. © 2005 Nature Publishing Group All rights reserved.
Scientific Publication
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