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Selective inhibition of herpes simplex virus type 1 DNA polymerase by zinc ions
Year:
1978
Source of publication :
Virology
Authors :
Chejanovsky, Nor
;
.
Volume :
84
Co-Authors:
Fridlender, B., Laboratory for Molecular Viorlogy, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Chejanovsky, N., Laboratory for Molecular Viorlogy, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Becker, Y., Laboratory for Molecular Viorlogy, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Facilitators :
From page:
551
To page:
554
(
Total pages:
4
)
Abstract:
The DNA polymerase of herpes simplex virus (HSV) was isolated from nuclei of infected BSC-1 cells by centrifugation in sucrose gradients and by chromatography on double-stranded DNA cellulose columns. The viral enzyme was almost completely inhibited in vitro by 0.1 mM zinc acetate. The a and β cellular DNA polymerases were resistant to 0.3 mM zinc acetate when tested under in vitro conditions. Inhibition of HSV replication can be explained by the selective inhibitory effect of zinc ions on the viral DNA polymerase. © 1978.
Note:
Related Files :
cell line
cell nucleus
DNA-Directed DNA Polymerase
phosphonoacetic acid
Simplexvirus
Zinc
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More details
DOI :
10.1016/0042-6822(78)90274-X
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
30040
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:51
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Scientific Publication
Selective inhibition of herpes simplex virus type 1 DNA polymerase by zinc ions
84
Fridlender, B., Laboratory for Molecular Viorlogy, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Chejanovsky, N., Laboratory for Molecular Viorlogy, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Becker, Y., Laboratory for Molecular Viorlogy, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Selective inhibition of herpes simplex virus type 1 DNA polymerase by zinc ions
The DNA polymerase of herpes simplex virus (HSV) was isolated from nuclei of infected BSC-1 cells by centrifugation in sucrose gradients and by chromatography on double-stranded DNA cellulose columns. The viral enzyme was almost completely inhibited in vitro by 0.1 mM zinc acetate. The a and β cellular DNA polymerases were resistant to 0.3 mM zinc acetate when tested under in vitro conditions. Inhibition of HSV replication can be explained by the selective inhibitory effect of zinc ions on the viral DNA polymerase. © 1978.
Scientific Publication
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