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Evidence for a direct effect of parathyroid on the metabolism of 25-hydroxycholecalciferol by chick kidney cells in vitro
Year:
1981
Authors :
Bär, Arie
;
.
Hurvitz, Shmuel
;
.
Maoz, Arieh
;
.
Volume :
68
Co-Authors:
Bar, A., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
Maoz, A., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
Hurwitz, S., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
Facilitators :
From page:
401
To page:
405
(
Total pages:
5
)
Abstract:
1. 1. The production of 1,25 hydroxycholecalciferol (1,25-(OH)2D3) by dispersed kidney cells obtained from vitamin D or calcium deficient, and from vitamin D-fed or repleted birds, was evaluated. 2. 2. Once stimulated in vivo by vitamin D or calcium deficiency, the kidney cells continued the accelerated production of 1,25-(OH)2D3 for 3 hr, in vitro. 3. 3. Pure bovine parathyroid hormone and a homogenate, extract or TCA powder of chick parathyroid gland (PTG) increased significantly the production of 1,25-(OH)2D3 by kidney cells. 4. 4. The effect of avian PTG material on 24,25-(OH)2D3 (24,25-(OH)2D2) production was not significant. 5. 5. The effect of PTG homogenate was independent of calcium concentration in the incubation medium. A high calcium concentration (3.0 mM) somewhat reduced the formation in vitro of 1,25-(OH)2D3 but stimulated slightly the production of 24,25-(OH)2D3. 6. 6. The effect of parathyroid sources was significant in cells taken from vitamin D replete and not vitamin D deficient birds. © 1981.
Note:
Related Files :
animal experiment
calcitriol
drug metabolism
Kidney
kidney cell
Short survey / mini-review
thyroid extract
vitamin D deficiency
Show More
Related Content
More details
DOI :
10.1016/0305-0491(81)90147-4
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
30063
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:51
Scientific Publication
Evidence for a direct effect of parathyroid on the metabolism of 25-hydroxycholecalciferol by chick kidney cells in vitro
68
Bar, A., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
Maoz, A., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
Hurwitz, S., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
Evidence for a direct effect of parathyroid on the metabolism of 25-hydroxycholecalciferol by chick kidney cells in vitro
1. 1. The production of 1,25 hydroxycholecalciferol (1,25-(OH)2D3) by dispersed kidney cells obtained from vitamin D or calcium deficient, and from vitamin D-fed or repleted birds, was evaluated. 2. 2. Once stimulated in vivo by vitamin D or calcium deficiency, the kidney cells continued the accelerated production of 1,25-(OH)2D3 for 3 hr, in vitro. 3. 3. Pure bovine parathyroid hormone and a homogenate, extract or TCA powder of chick parathyroid gland (PTG) increased significantly the production of 1,25-(OH)2D3 by kidney cells. 4. 4. The effect of avian PTG material on 24,25-(OH)2D3 (24,25-(OH)2D2) production was not significant. 5. 5. The effect of PTG homogenate was independent of calcium concentration in the incubation medium. A high calcium concentration (3.0 mM) somewhat reduced the formation in vitro of 1,25-(OH)2D3 but stimulated slightly the production of 24,25-(OH)2D3. 6. 6. The effect of parathyroid sources was significant in cells taken from vitamin D replete and not vitamin D deficient birds. © 1981.
Scientific Publication
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