נגישות
menu      
Advanced Search
Syntax
Search...
Volcani treasures
About
Terms of use
Manage
Community:
אסיף מאגר המחקר החקלאי
Powered by ClearMash Solutions Ltd -
αMUPA mice: A transgenic model for increased life span
Year:
1999
Source of publication :
Neurobiology of Aging
Authors :
Shinder, Dmitry A.
;
.
Yahav, Shlomo
;
.
Volume :
20
Co-Authors:
Miskina, R., Depts. of Biol. Chem. and Immunology, The Weizmann Inst. of Science, 76100, Rehovot, Israel
Masos, T., Depts. of Biol. Chem. and Immunology, The Weizmann Inst. of Science, 76100, Rehovot, Israel
Yahav, S., Institute of Animal Science, Agricultural Research Organization, Bet Dagan, Israel
Shinder, D., Institute of Animal Science, Agricultural Research Organization, Bet Dagan, Israel
Globerson, A., Depts. of Biol. Chem. and Immunology, The Weizmann Inst. of Science, 76100, Rehovot, Israel
Facilitators :
From page:
555
To page:
564
(
Total pages:
10
)
Abstract:
αMUPA is a line of transgenic mice that, compared with their wild type (WT) counterparts, spontaneously eat less (~20%) and live longer (average ~20%), thus resembling dietary-restricted (DR) mice. Here, we show that body temperature was significantly reduced in αMUPA compared with WT throughout a wide range of ages. Plasma corticosterone was significantly higher in young αMUPA compared to young WT; however, it significantly declined in aged αMUPA, but not in aged WT. In addition, age-associated thymus involution occurred in αMUPA as it did in WT. Thus αMUPA mice appear to largely resemble, but also to somewhat differ from diet-restricted animals. We also report on four new transgenic lines that, like αMUPA, produced in the brain the mRNA that encodes the extracellular protease urokinase (uPA); however, transgenic uPA expression was most extensive and widespread in the αMUPA brain, where it also occurred in the hypothalamus. αMUPA was also the only line that ate less, but also showed another characteristic, high frequency leg muscle tremor seen only at unstable body states. We hypothesize that transgenic uPA in the brain could have caused the αMUPA phenotypic alterations. Thus αMUPA offers a unique transgenic model of inherently reduced eating to investigate the homeostatic state of delayed aging at the systemic and single-cell levels. Copyright (C) 1999 Elsevier Science Inc.
Note:
Related Files :
Animal
animal experiment
Animals
Blood
corticosterone
Female
Genetics
mice
phenotype
thymus
Show More
Related Content
More details
DOI :
10.1016/S0197-4580(99)00093-7
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
30097
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:52
You may also be interested in
Scientific Publication
αMUPA mice: A transgenic model for increased life span
20
Miskina, R., Depts. of Biol. Chem. and Immunology, The Weizmann Inst. of Science, 76100, Rehovot, Israel
Masos, T., Depts. of Biol. Chem. and Immunology, The Weizmann Inst. of Science, 76100, Rehovot, Israel
Yahav, S., Institute of Animal Science, Agricultural Research Organization, Bet Dagan, Israel
Shinder, D., Institute of Animal Science, Agricultural Research Organization, Bet Dagan, Israel
Globerson, A., Depts. of Biol. Chem. and Immunology, The Weizmann Inst. of Science, 76100, Rehovot, Israel
αMUPA mice: A transgenic model for increased life span
αMUPA is a line of transgenic mice that, compared with their wild type (WT) counterparts, spontaneously eat less (~20%) and live longer (average ~20%), thus resembling dietary-restricted (DR) mice. Here, we show that body temperature was significantly reduced in αMUPA compared with WT throughout a wide range of ages. Plasma corticosterone was significantly higher in young αMUPA compared to young WT; however, it significantly declined in aged αMUPA, but not in aged WT. In addition, age-associated thymus involution occurred in αMUPA as it did in WT. Thus αMUPA mice appear to largely resemble, but also to somewhat differ from diet-restricted animals. We also report on four new transgenic lines that, like αMUPA, produced in the brain the mRNA that encodes the extracellular protease urokinase (uPA); however, transgenic uPA expression was most extensive and widespread in the αMUPA brain, where it also occurred in the hypothalamus. αMUPA was also the only line that ate less, but also showed another characteristic, high frequency leg muscle tremor seen only at unstable body states. We hypothesize that transgenic uPA in the brain could have caused the αMUPA phenotypic alterations. Thus αMUPA offers a unique transgenic model of inherently reduced eating to investigate the homeostatic state of delayed aging at the systemic and single-cell levels. Copyright (C) 1999 Elsevier Science Inc.
Scientific Publication
You may also be interested in