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אסיף מאגר המחקר החקלאי
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A search for bcl1, bcl2, and c-myc oncogene rearrangements in chronic lymphocytic leukemia
Year:
1989
Source of publication :
Leukemia
Authors :
Katzir, Nurit
;
.
Volume :
3
Co-Authors:
Rechavi, G., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Katzir, N., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Brok-Simoni, F., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Holtzman, F., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Mandel, M., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Gurfinkel, N., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Givol, D., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Ben-Bassat, I., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Ramot, B., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Facilitators :
From page:
57
To page:
60
(
Total pages:
4
)
Abstract:
Three cellular or putative oncogenes: c-myc, bcl1, and bcl2 were previously found to be rearranged in some B cell malignancies due to chromosomal translocations. Data concerning the role of such genetic rearrangements in B-CLL are very scanty and limited to few cases in which bcl1 rearrangements were found. We studied DNA samples from 38 cases of B-CLL by Southern blot technique in order to find out the existence and frequency of such events. No bcl1 or bcl2 rearrangements were found in any of the studied cases; thus, involvement of these genes in CLL must be rare. In one patient who had an aggressive and resistant disease, c-myc rearrangement was found.
Note:
Related Files :
adult
clinical article
human cell
Male
Oncogene
Translocation (Genetics)
Show More
Related Content
More details
DOI :
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
30136
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:52
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Scientific Publication
A search for bcl1, bcl2, and c-myc oncogene rearrangements in chronic lymphocytic leukemia
3
Rechavi, G., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Katzir, N., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Brok-Simoni, F., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Holtzman, F., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Mandel, M., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Gurfinkel, N., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Givol, D., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Ben-Bassat, I., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
Ramot, B., Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer 52 621, Israel
A search for bcl1, bcl2, and c-myc oncogene rearrangements in chronic lymphocytic leukemia
Three cellular or putative oncogenes: c-myc, bcl1, and bcl2 were previously found to be rearranged in some B cell malignancies due to chromosomal translocations. Data concerning the role of such genetic rearrangements in B-CLL are very scanty and limited to few cases in which bcl1 rearrangements were found. We studied DNA samples from 38 cases of B-CLL by Southern blot technique in order to find out the existence and frequency of such events. No bcl1 or bcl2 rearrangements were found in any of the studied cases; thus, involvement of these genes in CLL must be rare. In one patient who had an aggressive and resistant disease, c-myc rearrangement was found.
Scientific Publication
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