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The role of atrial natriuretic peptide in the diuretic effect of Ca2+ entry blockers
Year:
1993
Source of publication :
European Journal of Pharmacology
Authors :
Ezra, David
;
.
Volume :
233
Co-Authors:
Shamiss, A., Department of Medicine D, Chorley Hypertension Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
Peleg, E., Department of Medicine D, Chorley Hypertension Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
Rosenthal, T., Department of Medicine D, Chorley Hypertension Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
Ezra, D., Department of Medicine D, Chorley Hypertension Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
Facilitators :
From page:
113
To page:
117
(
Total pages:
5
)
Abstract:
The effect of three calcium entry blockers - verapamil, nifedipine and felodipine - on diuresis, natriuresis, the renin-aldosterone axis, and atrial natriuretic peptide (ANP) levels was studied in 30 previously untreated patients with mild to moderate essential hypertension. All three blockers produced significant antihypertensive effects after 2 and after 24 h. Heart rate tended to decrease, but did not change significantly after verapamil, but increased significantly 1-2 h after nifedipine and felodipine. Plasma renin activity (PRA) did not change significantly with any treatment, and plasma aldosterone decreased with all three agents. ANP levels did not change significantly after verapamil, but increased significantly after nifedipine and felodipine. There was a significant positive correlation between the maximal change in ANP level and urinary sodium after nifedipine and felodipine. The increase in urinary sodium after verapamil was not significant. The role of the direct renal effect of calcium entry blockers in their persistent natriuretic action is discussed, as well as their short-term enhancement of ANP levels, which may account for the initial diuretic and natriuretic effects seen with this class of dihydropiridines. © 1993.
Note:
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More details
DOI :
10.1016/0014-2999(93)90356-M
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
30200
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:52
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Scientific Publication
The role of atrial natriuretic peptide in the diuretic effect of Ca2+ entry blockers
233
Shamiss, A., Department of Medicine D, Chorley Hypertension Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
Peleg, E., Department of Medicine D, Chorley Hypertension Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
Rosenthal, T., Department of Medicine D, Chorley Hypertension Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
Ezra, D., Department of Medicine D, Chorley Hypertension Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
The role of atrial natriuretic peptide in the diuretic effect of Ca2+ entry blockers
The effect of three calcium entry blockers - verapamil, nifedipine and felodipine - on diuresis, natriuresis, the renin-aldosterone axis, and atrial natriuretic peptide (ANP) levels was studied in 30 previously untreated patients with mild to moderate essential hypertension. All three blockers produced significant antihypertensive effects after 2 and after 24 h. Heart rate tended to decrease, but did not change significantly after verapamil, but increased significantly 1-2 h after nifedipine and felodipine. Plasma renin activity (PRA) did not change significantly with any treatment, and plasma aldosterone decreased with all three agents. ANP levels did not change significantly after verapamil, but increased significantly after nifedipine and felodipine. There was a significant positive correlation between the maximal change in ANP level and urinary sodium after nifedipine and felodipine. The increase in urinary sodium after verapamil was not significant. The role of the direct renal effect of calcium entry blockers in their persistent natriuretic action is discussed, as well as their short-term enhancement of ANP levels, which may account for the initial diuretic and natriuretic effects seen with this class of dihydropiridines. © 1993.
Scientific Publication
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