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Gorelick, J., Eastern Regional Research and Development Center, Judea Center, Kiryat Arba, Israel
Yarmolinsky, L., Eastern Regional Research and Development Center, Judea Center, Kiryat Arba, Israel
Budovsky, A., Eastern Regional Research and Development Center, Judea Center, Kiryat Arba, Israel
Khalfin, B., Department of Clinical Biochemistry and Pharmacy, Ben-Gurion University of the Negev, Beer Sheva, Israel
Klein, J.D., Institute of Plant Sciences, ARO-Volcani Center, Rishon LeZion, Israel
Pinchasov, Y., Siap Laboratory, Rehovot, Israel
Bushuev, M.A., Department of Information Science and Systems, Morgan State University, Baltimore, MD, United States
Rudchenko, T., Scheller College of Business at Georgia Tech, Atlanta, GA, United States
Ben-Shabat, S., Department of Clinical Biochemistry and Pharmacy, Ben-Gurion University of the Negev, Beer Sheva, Israel
Nutrition, especially wheat consumption, is a major factor involved in the onset of type 1 diabetes (T1D) and other autoimmune diseases such as celiac. While modern wheat cultivars possess similar gliadin proteins associated with the onset of celiac disease and T1D, alternative dietary wheat sources from Israeli landraces and native ancestral species may be lacking the epitopes linked with T1D, potentially reducing the incidence of T1D. The Non-Obese Diabetic (NOD) mouse model was used to monitor the effects of dietary wheat sources on the onset and development of T1D. The effects of modern wheat flour were compared with those from either T. aestivum, T. turgidum spp. Dico zccoides, or T. turgidum spp. dicoccum landraces or a non-wheat diet. Animals which received wheat from local landraces or ancestral species such as emmer displayed a lower incidence of T1D and related complications compared to animals fed a modern wheat variety. This study is the first report of the diabetogenic properties of various dietary wheat sources and suggests that alternative dietary wheat sources may lack T1D linked epitopes, thus reducing the incidence of T1D. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
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The impact of diet wheat source on the onset of type 1 diabetes mellitus—lessons learned from the non-obese diabetic (NOD) mouse model
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Gorelick, J., Eastern Regional Research and Development Center, Judea Center, Kiryat Arba, Israel
Yarmolinsky, L., Eastern Regional Research and Development Center, Judea Center, Kiryat Arba, Israel
Budovsky, A., Eastern Regional Research and Development Center, Judea Center, Kiryat Arba, Israel
Khalfin, B., Department of Clinical Biochemistry and Pharmacy, Ben-Gurion University of the Negev, Beer Sheva, Israel
Klein, J.D., Institute of Plant Sciences, ARO-Volcani Center, Rishon LeZion, Israel
Pinchasov, Y., Siap Laboratory, Rehovot, Israel
Bushuev, M.A., Department of Information Science and Systems, Morgan State University, Baltimore, MD, United States
Rudchenko, T., Scheller College of Business at Georgia Tech, Atlanta, GA, United States
Ben-Shabat, S., Department of Clinical Biochemistry and Pharmacy, Ben-Gurion University of the Negev, Beer Sheva, Israel
The impact of diet wheat source on the onset of type 1 diabetes mellitus—lessons learned from the non-obese diabetic (NOD) mouse model
Nutrition, especially wheat consumption, is a major factor involved in the onset of type 1 diabetes (T1D) and other autoimmune diseases such as celiac. While modern wheat cultivars possess similar gliadin proteins associated with the onset of celiac disease and T1D, alternative dietary wheat sources from Israeli landraces and native ancestral species may be lacking the epitopes linked with T1D, potentially reducing the incidence of T1D. The Non-Obese Diabetic (NOD) mouse model was used to monitor the effects of dietary wheat sources on the onset and development of T1D. The effects of modern wheat flour were compared with those from either T. aestivum, T. turgidum spp. Dico zccoides, or T. turgidum spp. dicoccum landraces or a non-wheat diet. Animals which received wheat from local landraces or ancestral species such as emmer displayed a lower incidence of T1D and related complications compared to animals fed a modern wheat variety. This study is the first report of the diabetogenic properties of various dietary wheat sources and suggests that alternative dietary wheat sources may lack T1D linked epitopes, thus reducing the incidence of T1D. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
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