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Modulation of protein tyrosine phosphorylation in rat insular cortex after conditioned taste aversion training
Year:
1995
Authors :
Meiri, Noam
;
.
Volume :
92
Co-Authors:
Rosenblum, K., Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Schul, R., Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Meiri, N., Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Hadari, Y.R., Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Zick, Y., Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Dudai, Y., Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Facilitators :
From page:
1157
To page:
1161
(
Total pages:
5
)
Abstract:
Protein tyrosine phosphorylation is a major signal transduction pathway involved in cellular metabolism, growth, and differentiation. Recent data indicate that tyrosine phosphorylation also plays a role in neuronal plasticity. We are using conditioned taste aversion, a fast and robust associative learning paradigm subserved among other brain areas by the insular cortex, to investigate molecular correlates of learning and memory in the rat cortex. In conditioned taste aversion, rats learn to associate a novel taste (e.g., saccharin) with delayed poisoning (e.g., by LiCl injection). Here we report that after conditioned taste aversion training, there is a rapid and marked increase in tyrosine phosphorylation of a set of proteins in the insular cortex but not in other brain areas. A major protein so modulated, of 180 kDa, is abundant in a membrane fraction and remains modulated for more than an hour after training. Exposure of the rats to the novel taste alone results in only a small modulation of the aforementioned proteins whereas administration of the malaise-inducing agent per se has no effect. To the best of our knowledge, this is the first demonstration of modulation of protein tyrosine phosphorylation in the brain after a behavioral experience.
Note:
Related Files :
Animal
animal cell
animal experiment
animal tissue
cellular distribution
Cerebral Cortex
Male
taste
tyrosine
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More details
DOI :
10.1073/pnas.92.4.1157
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
30563
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:55
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Scientific Publication
Modulation of protein tyrosine phosphorylation in rat insular cortex after conditioned taste aversion training
92
Rosenblum, K., Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Schul, R., Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Meiri, N., Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Hadari, Y.R., Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Zick, Y., Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Dudai, Y., Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Modulation of protein tyrosine phosphorylation in rat insular cortex after conditioned taste aversion training
Protein tyrosine phosphorylation is a major signal transduction pathway involved in cellular metabolism, growth, and differentiation. Recent data indicate that tyrosine phosphorylation also plays a role in neuronal plasticity. We are using conditioned taste aversion, a fast and robust associative learning paradigm subserved among other brain areas by the insular cortex, to investigate molecular correlates of learning and memory in the rat cortex. In conditioned taste aversion, rats learn to associate a novel taste (e.g., saccharin) with delayed poisoning (e.g., by LiCl injection). Here we report that after conditioned taste aversion training, there is a rapid and marked increase in tyrosine phosphorylation of a set of proteins in the insular cortex but not in other brain areas. A major protein so modulated, of 180 kDa, is abundant in a membrane fraction and remains modulated for more than an hour after training. Exposure of the rats to the novel taste alone results in only a small modulation of the aforementioned proteins whereas administration of the malaise-inducing agent per se has no effect. To the best of our knowledge, this is the first demonstration of modulation of protein tyrosine phosphorylation in the brain after a behavioral experience.
Scientific Publication
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