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Reduced affinity of intestinal receptors for 1,25-dihydroxycholecalciferol in phosphorus-deficient chicks
Year:
1986
Source of publication :
Journal of Endocrinology
Authors :
Bär, Arie
;
.
Hurvitz, Shmuel (Animal science)
;
.
Volume :
110
Co-Authors:
Bar, A., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Bet Dagan 50250, Israel
Hurwitz, S., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
217
To page:
223
(
Total pages:
7
)
Abstract:
The binding of 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) to its intestinal receptor was studied in chicks fed a phosphorus (P)-deficient diet. The equilibrium association constant (K(a)) was determined by Scatchard analysis. Association (K(ass)) and dissociation (K(dis) rate constants were determined in experiments on hormone uptake and release respectively. The K(a), determined at 4,12 and 19° C, decreased progressively during P deficiency, due to the decrease in K(ass), but K(dis) was not affected. During prolonged P deficiency the concentration of binding sites (N(max)) also decreased. Duodenal calcium-binding protein (CaBP) increased during 10 days of P deficiency and then decreased. The long-term decrease in receptor affinity and N(max) may account for the observed reduction in receptor occupancy and the decrease in the high level of intestinal CaBP stimulated during early P deficiency. The resulting decrease in Ca absorption may minimize the hypercalcaemia induced by the deficiency.
Note:
Related Files :
Animal
animal cell
Binding Sites
calcitriol
calcitriol receptor
Chickens
Duodenum
Intestinal Mucosa
Male
Show More
Related Content
More details
DOI :
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
30660
Last updated date:
21/08/2022 07:45
Creation date:
17/04/2018 00:56
Scientific Publication
Reduced affinity of intestinal receptors for 1,25-dihydroxycholecalciferol in phosphorus-deficient chicks
110
Bar, A., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Bet Dagan 50250, Israel
Hurwitz, S., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Bet Dagan 50250, Israel
Reduced affinity of intestinal receptors for 1,25-dihydroxycholecalciferol in phosphorus-deficient chicks
The binding of 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) to its intestinal receptor was studied in chicks fed a phosphorus (P)-deficient diet. The equilibrium association constant (K(a)) was determined by Scatchard analysis. Association (K(ass)) and dissociation (K(dis) rate constants were determined in experiments on hormone uptake and release respectively. The K(a), determined at 4,12 and 19° C, decreased progressively during P deficiency, due to the decrease in K(ass), but K(dis) was not affected. During prolonged P deficiency the concentration of binding sites (N(max)) also decreased. Duodenal calcium-binding protein (CaBP) increased during 10 days of P deficiency and then decreased. The long-term decrease in receptor affinity and N(max) may account for the observed reduction in receptor occupancy and the decrease in the high level of intestinal CaBP stimulated during early P deficiency. The resulting decrease in Ca absorption may minimize the hypercalcaemia induced by the deficiency.
Scientific Publication
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