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Calcium and Inorganic Phosphorus Metabolism in Naked Mole Rats Heterocephalus glaber Is Only Indirectly Affected by Cholecalciferol
Year:
1993
Authors :
Yahav, Shlomo
;
.
Volume :
89
Co-Authors:
Yahav, S., MRC Mineral Metabolism Research Unit, Department of Paediatrics, University of the Witwatersrand, Baragwanath Hospital, Johannesburg, South Africa
and Department of Physiology, Medical School of the University of the Witwatersrand, 7 York Road, Parktown 2193, South Africa
Buffenstein, R., MRC Mineral Metabolism Research Unit, Department of Paediatrics, University of the Witwatersrand, Baragwanath Hospital, Johannesburg, South Africa
Pettifor, J.M., MRC Mineral Metabolism Research Unit, Department of Paediatrics, University of the Witwatersrand, Baragwanath Hospital, Johannesburg, South Africa
Facilitators :
From page:
161
To page:
166
(
Total pages:
6
)
Abstract:
Naked mole rats seem to be naturally deficient in cholecalciferol yet exhibit net calcium and inorganic phosphorus absorption efficiencies that approach a physiological maximum (i.e., exceed 94%). Oral supplementation with cholecalciferol therefore does not markedly enhance the efficiency of gastrointestinal absorption of these minerals, but rather exerts indirect effects on mineral metabolism by increasing food intake (1.7 ×) from 3.6 ± 0.4 to 6.2 ± 0.3 g/100 g body wt day -1. This, in turn, results in a concomitant increase in the daily rate of calcium absorption from 2.9 ± 0.3 to 4.4 ± 0.4 (mmol/100 g body wt day-1) and inorganic phosphorus absorption from 4.5 ± 0.4 to 7.9 ± 0.4 (mmol/100 g body wt day-1) with cholecalciferol supplementation. Excretion of calcium decreases from 2.9 ± 0.5 to 1.2 ± 0.4 μmol/100 g body wt day-1 with cholecalciferol supplementation whereas inorganic phosphorus excretion is unchanged (4.3 ± 0.9 to 4.3 ± 1.2 μmol/100 g body wt day-1), to give a positive mineral balance, without any evident pathology. Indeed serum calcium (2.3 ± 0.1 vs 2.5 ± 0.1 mmol/liter) and inorganic phosphorus (1.5 ± 0.3 vs 1.6 ± 0.2 mmol/liter) concentrations remain tightly regulated irrespective of vitamin D3 status. Mineral balance in naked mole rats is concluded not to he directly influenced by cholecalciferol, rather it may be affected by pleiotropic actions of cholecalciferol on gut function. © 1993 Academic Press. All rights reserved.
Note:
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More details
DOI :
10.1006/gcen.1993.1019
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
30691
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:56
Scientific Publication
Calcium and Inorganic Phosphorus Metabolism in Naked Mole Rats Heterocephalus glaber Is Only Indirectly Affected by Cholecalciferol
89
Yahav, S., MRC Mineral Metabolism Research Unit, Department of Paediatrics, University of the Witwatersrand, Baragwanath Hospital, Johannesburg, South Africa
and Department of Physiology, Medical School of the University of the Witwatersrand, 7 York Road, Parktown 2193, South Africa
Buffenstein, R., MRC Mineral Metabolism Research Unit, Department of Paediatrics, University of the Witwatersrand, Baragwanath Hospital, Johannesburg, South Africa
Pettifor, J.M., MRC Mineral Metabolism Research Unit, Department of Paediatrics, University of the Witwatersrand, Baragwanath Hospital, Johannesburg, South Africa
Calcium and Inorganic Phosphorus Metabolism in Naked Mole Rats Heterocephalus glaber Is Only Indirectly Affected by Cholecalciferol
Naked mole rats seem to be naturally deficient in cholecalciferol yet exhibit net calcium and inorganic phosphorus absorption efficiencies that approach a physiological maximum (i.e., exceed 94%). Oral supplementation with cholecalciferol therefore does not markedly enhance the efficiency of gastrointestinal absorption of these minerals, but rather exerts indirect effects on mineral metabolism by increasing food intake (1.7 ×) from 3.6 ± 0.4 to 6.2 ± 0.3 g/100 g body wt day -1. This, in turn, results in a concomitant increase in the daily rate of calcium absorption from 2.9 ± 0.3 to 4.4 ± 0.4 (mmol/100 g body wt day-1) and inorganic phosphorus absorption from 4.5 ± 0.4 to 7.9 ± 0.4 (mmol/100 g body wt day-1) with cholecalciferol supplementation. Excretion of calcium decreases from 2.9 ± 0.5 to 1.2 ± 0.4 μmol/100 g body wt day-1 with cholecalciferol supplementation whereas inorganic phosphorus excretion is unchanged (4.3 ± 0.9 to 4.3 ± 1.2 μmol/100 g body wt day-1), to give a positive mineral balance, without any evident pathology. Indeed serum calcium (2.3 ± 0.1 vs 2.5 ± 0.1 mmol/liter) and inorganic phosphorus (1.5 ± 0.3 vs 1.6 ± 0.2 mmol/liter) concentrations remain tightly regulated irrespective of vitamin D3 status. Mineral balance in naked mole rats is concluded not to he directly influenced by cholecalciferol, rather it may be affected by pleiotropic actions of cholecalciferol on gut function. © 1993 Academic Press. All rights reserved.
Scientific Publication
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