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Recent developments in organically doped sol-gel sensors: A microns-scale probe; successful trapping of purified polyclonal antibodies; solutions to the dopant-leaching problem
Year:
1994
Authors :
Aharonson, Nadav
;
.
Altstein, Miriam
;
.
Bronshtein, Alisa
;
.
Volume :
346
Co-Authors:

Aharonson, N., Volcani Cent, Beit Dagan, Israel
Altstein, M., Volcani Cent, Beit Dagan, Israel
Avidan, G. 
Avnir, D.
Bronshtein, A., Volcani Cent, Beit Dagan, Israel
Lewis, A.
Liberman, K.
Ottolenghi, M.
Polevaya, Y.
Rottman, C.
Samuel, J.
Shalom, S.
Strinkovski, A.
Turniansky, A.

Facilitators :
From page:
519
To page:
530
(
Total pages:
12
)
Abstract:
We describe recent advances made in our laboratories in the general field of organically and bio-organically doped sol-gel sensors. The developments described are: (a) The first miniaturization of a sol-gel sensor down to the microns scale, with potential applications to near-field optical microscopy, using a fluorescent pH-indicator. (b) The first successful sol-gel encapsulation of purified polyclonal antibodies, and in particular an anti-nitroaromatics immunoglobulin, with which selective sensing of nitroaromatics, an important class of environmental pollutants, was demonstrated. (c) The leaching problem, occasionally encountered in doping procedures, is solved by two methodologies: First, TMOS polymerization at high acidity and low water content was found to result in non-leachable yet reactive matrices, as demonstrated with O2 sensing by excited state pyrene and with H+ sensing by excited state pyranine; and second, doping with molecules capable of forming a covalent bond within the encapsulating cage results in the permanent anchoring of the dopant. Thus, Methyl-Red, a pH indicator, was derivatized with a silylating residue, and a polymerizing TMOS was doped with it forming a pH-shifted indicator. With both methodologies, leachability was practically zero.
Note:
Related Files :
Biosensors
Derivatives
Dopant leaching problem
Doping (additives)
pH sensors
Polymerization
Sol-gels
Sol gel sensors
Show More
Related Content
More details
DOI :
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
Conference paper
;
.
Language:
English
Editors' remarks:
ID:
30696
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:56
Scientific Publication
Recent developments in organically doped sol-gel sensors: A microns-scale probe; successful trapping of purified polyclonal antibodies; solutions to the dopant-leaching problem
346

Aharonson, N., Volcani Cent, Beit Dagan, Israel
Altstein, M., Volcani Cent, Beit Dagan, Israel
Avidan, G. 
Avnir, D.
Bronshtein, A., Volcani Cent, Beit Dagan, Israel
Lewis, A.
Liberman, K.
Ottolenghi, M.
Polevaya, Y.
Rottman, C.
Samuel, J.
Shalom, S.
Strinkovski, A.
Turniansky, A.

Recent developments in organically doped sol-gel sensors: A microns-scale probe; successful trapping of purified polyclonal antibodies; solutions to the dopant-leaching problem
We describe recent advances made in our laboratories in the general field of organically and bio-organically doped sol-gel sensors. The developments described are: (a) The first miniaturization of a sol-gel sensor down to the microns scale, with potential applications to near-field optical microscopy, using a fluorescent pH-indicator. (b) The first successful sol-gel encapsulation of purified polyclonal antibodies, and in particular an anti-nitroaromatics immunoglobulin, with which selective sensing of nitroaromatics, an important class of environmental pollutants, was demonstrated. (c) The leaching problem, occasionally encountered in doping procedures, is solved by two methodologies: First, TMOS polymerization at high acidity and low water content was found to result in non-leachable yet reactive matrices, as demonstrated with O2 sensing by excited state pyrene and with H+ sensing by excited state pyranine; and second, doping with molecules capable of forming a covalent bond within the encapsulating cage results in the permanent anchoring of the dopant. Thus, Methyl-Red, a pH indicator, was derivatized with a silylating residue, and a polymerizing TMOS was doped with it forming a pH-shifted indicator. With both methodologies, leachability was practically zero.
Scientific Publication
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