Co-Authors:
Svoboda, J.A., Insect Physiology Laboratory, Entomology Research Division, U.S. Dept. of Agriculture, Beltsville, 20705, Maryland, United States
Robbins, W.E., Insect Physiology Laboratory, Entomology Research Division, U.S. Dept. of Agriculture, Beltsville, 20705, Maryland, United States
Abstract:
Several monoazasterols were found to be potent inhibitors of Δ24- and Δ22,24- reductase enzyme(s) in the tobacco hornworm, Manduca sexta (Johannson). Certain of these inhibitors also prevented normal larval development and pupation in the hornworm at dietary concentrations in the parts per million range. Comparative studies with several different insects indicated differences between the species with respect to the effects of the azasterols. The relationship of azasterol structure to the inhibitory effect(s) on sterol metabolism and larval development is discussed. © 1971 American Oil Chemists' Society.