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Downregulation of microglial activation by achillolide A
Year:
2015
Source of publication :
Planta Medica
Authors :
Elmann, Anat
;
.
Erlank, Hilla
;
.
Rindner, Miriam
;
.
Telerman, Alona
;
.
Volume :
81
Co-Authors:
Elmann, A., Department of Food Quality and Safety, Volcani Center, Agricultural Research Organization, Bet Dagan, Israel
Telerman, A., Department of Food Quality and Safety, Volcani Center, Agricultural Research Organization, Bet Dagan, Israel
Mordechay, S., Department of Food Quality and Safety, Volcani Center, Agricultural Research Organization, Bet Dagan, Israel, Faculty of Agriculture, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot, Israel
Erlank, H., Department of Food Quality and Safety, Volcani Center, Agricultural Research Organization, Bet Dagan, Israel, Faculty of Agriculture, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot, Israel
Rindner, M., Department of Food Quality and Safety, Volcani Center, Agricultural Research Organization, Bet Dagan, Israel
Kashman, Y., School of Chemistry, Tel Aviv University, Ramat Aviv, Israel
Ofir, R., Dead Sea and Arava Science Center and Regenerative Medicine, Stem Cell Research Center, Ben-Gurion University of the Negev, Beer-Sheba, Israel
Facilitators :
From page:
215
To page:
221
(
Total pages:
7
)
Abstract:
Chronic inflammation has been implicated in the pathogenesis of various neurodegenerative diseases. During the neuroinflammatory process, microglial cells release neurotoxic and proinflammatory mediators. In the present study, using activity-guided fractionation, we have purified an anti-inflammatory compound determined by spectroscopic methods to be a sesquiterpene lactone named achillolide A from Achillea fragrantissima (Forsk.) Sch. Bip. In primary cultures of lipopolysaccharide-activated microglial cells, achillolide A inhibited the lipopolysaccharide-induced levels of proinflammatory and toxic mediators including glutamate, nitric oxide, matrix metalloproteinase-9, cyclooxygenase-2, induced nitric oxide synthase, interleukin-1β, and tumor necrosis factor-α. Achillolide A also exhibited an antioxidant capacity, as was shown in a cell free system as well as by its ability to reduce intracellular reactive oxygen species levels in microglial cells. Thus, achillolide A might have therapeutic potential for treatment of neurodegenerative diseases and deserves further studies.
Note:
Related Files :
Achillea
Animal
Animals
antioxidants
metabolism
neurodegenerative diseases
reactive oxygen species
Show More
Related Content
More details
DOI :
10.1055/s-0034-1396204
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
30837
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:57
Scientific Publication
Downregulation of microglial activation by achillolide A
81
Elmann, A., Department of Food Quality and Safety, Volcani Center, Agricultural Research Organization, Bet Dagan, Israel
Telerman, A., Department of Food Quality and Safety, Volcani Center, Agricultural Research Organization, Bet Dagan, Israel
Mordechay, S., Department of Food Quality and Safety, Volcani Center, Agricultural Research Organization, Bet Dagan, Israel, Faculty of Agriculture, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot, Israel
Erlank, H., Department of Food Quality and Safety, Volcani Center, Agricultural Research Organization, Bet Dagan, Israel, Faculty of Agriculture, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot, Israel
Rindner, M., Department of Food Quality and Safety, Volcani Center, Agricultural Research Organization, Bet Dagan, Israel
Kashman, Y., School of Chemistry, Tel Aviv University, Ramat Aviv, Israel
Ofir, R., Dead Sea and Arava Science Center and Regenerative Medicine, Stem Cell Research Center, Ben-Gurion University of the Negev, Beer-Sheba, Israel
Downregulation of microglial activation by achillolide A
Chronic inflammation has been implicated in the pathogenesis of various neurodegenerative diseases. During the neuroinflammatory process, microglial cells release neurotoxic and proinflammatory mediators. In the present study, using activity-guided fractionation, we have purified an anti-inflammatory compound determined by spectroscopic methods to be a sesquiterpene lactone named achillolide A from Achillea fragrantissima (Forsk.) Sch. Bip. In primary cultures of lipopolysaccharide-activated microglial cells, achillolide A inhibited the lipopolysaccharide-induced levels of proinflammatory and toxic mediators including glutamate, nitric oxide, matrix metalloproteinase-9, cyclooxygenase-2, induced nitric oxide synthase, interleukin-1β, and tumor necrosis factor-α. Achillolide A also exhibited an antioxidant capacity, as was shown in a cell free system as well as by its ability to reduce intracellular reactive oxygen species levels in microglial cells. Thus, achillolide A might have therapeutic potential for treatment of neurodegenerative diseases and deserves further studies.
Scientific Publication
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