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אסיף מאגר המחקר החקלאי
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Recovery of Chinese hamster cells following photosensitization by zinc tetrahydroxyphthalocyanine
Year:
1988
Authors :
Rosenthal, Ionel
;
.
Volume :
2
Co-Authors:
Ben-Hur, E., Nuclear Research Center-Negev, P.O. Box 9001, Beer-Sheva, 84190, Israel
Rosenthal, I., Department of Food Science, The Volcani Center, P.O. Box 6, Bet-Dagan, 50 250, Israel
Leznoff, C.C., Department of Chemistry, York University, Ontario M3J IP3, North York, Canada
Facilitators :
From page:
243
To page:
252
(
Total pages:
10
)
Abstract:
The phthalocyanine dyes are attractive sensitizers for photodynamic therapy of cancer. The light fluence response curves for photocytotoxicity of zinc tetrahydroxyphthalocyanine were constructed using the colony-forming ability of Chinese hamster cells as an end-point. The survival curve of cells photosensitized to white light by this dye has a pronounced shoulder followed by an exponential decline. Postillumination hypertonic treatment (0.5 M NaCl for 20 min at 37 °C) enhanced log-phase killing, although to a lesser extent than after exposure to ionizing radiation. While such an enhancement usually indicates that the cells are able to repair potentially lethal damage, delayed trypsinization of photosensitized cells in plateau-phase failed to show a significant increase in cell survival. Thus, the repair of such a damage in plateau-phase is apparently absent. Experiments with split light fluence indicated that log-phase cells can repair sublethal damage during a 24 h interval, as evidenced by the reappearance of the shoulder on the split-dose survival curve. © 1988.
Note:
Related Files :
Animal
drug effect
Photosensitization
phthalocyanine
potentially lethal damage
Zinc
zinc tetrahydroxyphthalocyanine
Show More
Related Content
More details
DOI :
10.1016/1011-1344(88)80007-1
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
30943
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:58
Scientific Publication
Recovery of Chinese hamster cells following photosensitization by zinc tetrahydroxyphthalocyanine
2
Ben-Hur, E., Nuclear Research Center-Negev, P.O. Box 9001, Beer-Sheva, 84190, Israel
Rosenthal, I., Department of Food Science, The Volcani Center, P.O. Box 6, Bet-Dagan, 50 250, Israel
Leznoff, C.C., Department of Chemistry, York University, Ontario M3J IP3, North York, Canada
Recovery of Chinese hamster cells following photosensitization by zinc tetrahydroxyphthalocyanine
The phthalocyanine dyes are attractive sensitizers for photodynamic therapy of cancer. The light fluence response curves for photocytotoxicity of zinc tetrahydroxyphthalocyanine were constructed using the colony-forming ability of Chinese hamster cells as an end-point. The survival curve of cells photosensitized to white light by this dye has a pronounced shoulder followed by an exponential decline. Postillumination hypertonic treatment (0.5 M NaCl for 20 min at 37 °C) enhanced log-phase killing, although to a lesser extent than after exposure to ionizing radiation. While such an enhancement usually indicates that the cells are able to repair potentially lethal damage, delayed trypsinization of photosensitized cells in plateau-phase failed to show a significant increase in cell survival. Thus, the repair of such a damage in plateau-phase is apparently absent. Experiments with split light fluence indicated that log-phase cells can repair sublethal damage during a 24 h interval, as evidenced by the reappearance of the shoulder on the split-dose survival curve. © 1988.
Scientific Publication
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