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In vitro exposure of nasal epithelial cells to atmospheric dust
Year:
2018
Authors :
Zaady, Eli
;
.
Volume :
17
Co-Authors:
Elad, D., Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
Zaretsky, U., Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
Avraham, S., Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
Gotlieb, R., Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
Wolf, M., Department of Otorhinolaryngology, Sheba Medical Center, Tel Hashomer, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Katra, I., Department of Geography and Environmental Development, Ben Gurion University of the Negev, Beer Sheva, Israel
Sarig, S., The Katif Research Center, Sdot-Negev, Mobile Post Negev, Israel
Zaady, E., Department of Natural Resources, Agricultural Research Organization, Ministry of Agriculture, Gilat Research Center, Mobile Post Negev, Israel
Facilitators :
From page:
891
To page:
901
(
Total pages:
11
)
Abstract:
Dust storms are common phenomena in many parts of the world, and significantly increase the level of atmospheric particulate matter (PM). The soil-derived dust is a mixture of organic and inorganic particles and even remnants of pesticides from agricultural areas nearby. The risk of human exposure to atmospheric dust is well documented, but very little is known on the impact of inhaled PM on the biological lining of the nasal cavity, which is the natural filter between the external environment and the respiratory tract. We developed a new system and methodology for in vitro exposure of cultured nasal epithelial cells (NEC) to atmospheric soil-dust pollutants under realistic and controlled laboratory simulations that mimic nasal breathing. We exposed cultured NEC to clean and dust-polluted airflows that mimic physiological conditions. The results revealed that the secretion of mucin and IL-8 from the NEC exposed to clean and dust-polluted airflows was less than the secretion at static conditions under clean air. The secretion of IL-8 from NEC exposed to dust-polluted air was larger than that of clean air, but not larger than in the static case. The experiments with dust air pollution that also contained agricultural pesticides did not reveal differences in the secretion of mucin and IL-8 as compared to the same pollution without pesticides. © 2018 Springer-Verlag GmbH Germany, part of Springer Nature
Note:
Related Files :
Agriculture
metabolism
mucin
Nasal epithelium
pesticides
pollution
Simulation
Show More
Related Content
More details
DOI :
10.1007/s10237-017-0999-y
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
31047
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:59
Scientific Publication
In vitro exposure of nasal epithelial cells to atmospheric dust
17
Elad, D., Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
Zaretsky, U., Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
Avraham, S., Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
Gotlieb, R., Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
Wolf, M., Department of Otorhinolaryngology, Sheba Medical Center, Tel Hashomer, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Katra, I., Department of Geography and Environmental Development, Ben Gurion University of the Negev, Beer Sheva, Israel
Sarig, S., The Katif Research Center, Sdot-Negev, Mobile Post Negev, Israel
Zaady, E., Department of Natural Resources, Agricultural Research Organization, Ministry of Agriculture, Gilat Research Center, Mobile Post Negev, Israel
In vitro exposure of nasal epithelial cells to atmospheric dust
Dust storms are common phenomena in many parts of the world, and significantly increase the level of atmospheric particulate matter (PM). The soil-derived dust is a mixture of organic and inorganic particles and even remnants of pesticides from agricultural areas nearby. The risk of human exposure to atmospheric dust is well documented, but very little is known on the impact of inhaled PM on the biological lining of the nasal cavity, which is the natural filter between the external environment and the respiratory tract. We developed a new system and methodology for in vitro exposure of cultured nasal epithelial cells (NEC) to atmospheric soil-dust pollutants under realistic and controlled laboratory simulations that mimic nasal breathing. We exposed cultured NEC to clean and dust-polluted airflows that mimic physiological conditions. The results revealed that the secretion of mucin and IL-8 from the NEC exposed to clean and dust-polluted airflows was less than the secretion at static conditions under clean air. The secretion of IL-8 from NEC exposed to dust-polluted air was larger than that of clean air, but not larger than in the static case. The experiments with dust air pollution that also contained agricultural pesticides did not reveal differences in the secretion of mucin and IL-8 as compared to the same pollution without pesticides. © 2018 Springer-Verlag GmbH Germany, part of Springer Nature
Scientific Publication
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