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Calcium Antagonists: Drug Interactions of Clinical Significance
Year:
1995
Source of publication :
Drug Safety
Authors :
Ezra, David
;
.
Volume :
13
Co-Authors:
Rosenthal, T., A.J. Chorley Institute for Hypertension, Chaim Sheba Medical Center, Tel Hashomer, 52621, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Ezra, D., Clinical Pharmacology Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Facilitators :
From page:
157
To page:
187
(
Total pages:
31
)
Abstract:
The interaction of calcium antagonists, including the dihydropyridine calcium antagonists (e.g. nifedipine), verapamil and diltiazem, with drugs from other classes has major clinical ramifications as the use of drug combinations increases in frequency. Combinations are used in the treatment of disorders ranging from hypertension to cardiac rhythm disturbances, angina pectoris and peripheral vasospastic disease. In this era of organ transplantation, drugs like cyclosporin are coming into potential conflict with an ever-growing list of drugs. Drug combinations used as part of long term therapies are also making their appearance in toxic drug reactions, including antituberculous and anticonvulsant agents. Bronchodilators and H2-blockers also fall into this category of potential culprits of combined drug toxicity, and the interactions of calcium antagonists with β-blockers and antiarrhythmic agents are also becoming a matter of concern. © 1995, Adis International Limited. All rights reserved.
Note:
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More details
DOI :
10.2165/00002018-199513030-00003
Article number:
Affiliations:
Database:
Scopus
Publication Type:
Review
;
.
Language:
English
Editors' remarks:
ID:
31143
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:00
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Scientific Publication
Calcium Antagonists: Drug Interactions of Clinical Significance
13
Rosenthal, T., A.J. Chorley Institute for Hypertension, Chaim Sheba Medical Center, Tel Hashomer, 52621, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Ezra, D., Clinical Pharmacology Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Calcium Antagonists: Drug Interactions of Clinical Significance
The interaction of calcium antagonists, including the dihydropyridine calcium antagonists (e.g. nifedipine), verapamil and diltiazem, with drugs from other classes has major clinical ramifications as the use of drug combinations increases in frequency. Combinations are used in the treatment of disorders ranging from hypertension to cardiac rhythm disturbances, angina pectoris and peripheral vasospastic disease. In this era of organ transplantation, drugs like cyclosporin are coming into potential conflict with an ever-growing list of drugs. Drug combinations used as part of long term therapies are also making their appearance in toxic drug reactions, including antituberculous and anticonvulsant agents. Bronchodilators and H2-blockers also fall into this category of potential culprits of combined drug toxicity, and the interactions of calcium antagonists with β-blockers and antiarrhythmic agents are also becoming a matter of concern. © 1995, Adis International Limited. All rights reserved.
Scientific Publication
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